锡类散预防酸性灌肠液致兔肠黏膜损伤的实验研究  

Preventive effect of traditional Xilei powder on intestinal mucosal injury caused by acetic acid enema in rabbits

作　　者：沈美云[1] 张凤[2] 徐旭娟[1] 章建国[1] 吴倩[2] 

机构地区：[1]南通大学附属医院妇产科,江苏南通226001 [2]南通大学护理学院,江苏南通226001

出　　处：《护理学杂志》2011年第18期1-3,共3页

基　　金：南通市2008年指令性社会发展科技计划项目(S2008037)

摘　　要：目的观察锡类散预防酸性灌肠液灌肠所致兔肠黏膜损伤的效果。方法将40只家兔随机分成两组各20只,对照组采用食醋灌肠,观察组采用食醋加锡类散灌肠。观测两组灌肠前后血钾水平变化及粪便涂片肠黏膜细胞脱落情况;将动物腹腔麻醉下取直肠、结肠肠壁制作病理切片,透射电镜观察肠黏膜细胞亚显微结构变化,光镜观察肠黏膜充血、水肿情况。结果对照组灌肠后血钾下降水平较观察组更为显著(P<0.01);病理切片及粪便涂片显示,对照组肠黏膜损伤及肠黏膜细胞脱落情况较观察组严重。结论锡类散可降低酸性灌肠液对兔肠黏膜损伤程度,具有一定的保护作用。Objective To explore the preventive effect of traditional Xilei powder on intestinal mucosal injury caused by acetic acid enema in rabbits.Methods Forty rabbits were randomized into 2 groups of 20.The control group received acetic acid enema,while the observation group were given enema solution containing vinegar and Xilei powder.Serum potassium was detected before and after enema,and exfoliative cells were observed in the stool smear.Then,pathological sections of the rectum and colon were obtained when the rabbits were under intraperitoneal anesthesia.Submicroscopic structure of intestinal cells,and congestion and edema of intestinal mucosa were observed through electron microscope and optical microscope.Results The decrease of serum potassium in the control group was significantly greater than that in the observation group（P0.01）.Compared with the observation group,intestinal mucosal injury and exfoliation were more severe in the control group.Conclusion Xilei powder has some protective effect on injuries of intestinal mucosa caused by acetic acid enema.

关 键 词：家兔 灌肠 酸性灌肠液 锡类散 肠黏膜损伤 食醋 

分 类 号：R472.91[医药卫生—护理学]