超声光散射断层成像与乳腺癌微血管密度的相关性研究  

Correlation between Diffused Optical Tomography with Ultrasonography and Microvessel Density in Breast Cancer

作　　者：王红磊[1] 武力[1] 阙燕[1] 

机构地区：[1]兰州大学第一医院乳腺科,甘肃兰州730000

出　　处：《中山大学学报（医学科学版）》2011年第4期531-536,共6页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：【目的】探讨乳腺癌超声光散射断层成像综合诊断指数(SDI)与微血管密度(MVD)的关系以及它们与临床病理特征的关系。【方法】采用超声光散射断层成像系统,研究131例乳腺良性肿块及142例乳腺癌患者,测量超声光散射断层成像综合诊断指数通过受试者工作特征曲线(ROC)确定乳腺癌的最佳诊断阈值。使用免疫组化法检测乳腺癌CD105标记的微血管密度。【结果】乳腺良性疾病与乳腺癌的SDI值分别:109±48、191±60。两者之间的差异有统计学意义(P<0.05)。经ROC曲线分析可得:SDI值的ROC曲线下面积为0.889,确定SDI值>141.2作为乳腺癌的最佳诊断阈值。SDI值与MVD值呈正相关。SDI值、CD105标记的MVD值与肿瘤大小、淋巴结转移、TNM分期、CerbB-2表达有关(P<0.05),与ER、PR表达无关(P>0.05)。【结论】超声光散射断层成像综合诊断指数与乳腺癌微血管密度密切相关,可以间接反映血管生成活性,对于对乳腺癌的诊断、病情判断具有有重要的指导意义。[Objective] To investigate the correlation between synthesis diagnostic index（SDI） of diffused optical tomography（DOT） with ultrasonography（US） localization and microvessel density（MVD） based on CD105,as well as their relationship with clinic pathological characteristics of breast cancer.[Method] A new machine of diffused optical tomography（DOT） with ultrasonography（US） was used in diagnosis of 273 cases with breast cancer,in which 131 cases were benign and 142 cases were malignant.The machine generates a synthesis diagnostic index（SDI） as a quantitative measure of the likelihood of a lesion being malignant.The receiver operating characteristic（ROC） curve analysis was used to estimate the optimal diagnostic threshold of breast cancer.The microvessel density（MVD） based on CD105 was detected by immunohistochemistry on all the 142 cases of breast cancer.[Results] The mean SDI values were 109 ± 48 for benign cases and 191 ± 60 for malignant cases.There was significant difference between them（P 0.05）.According to ROC curve analysis,the areas under ROC curve of SDI was 0.889.The SDI has linear correlation with MVD of breast cancer（P 0.05）.The mean values of SDI and the MVD were significantly correlated with the tumor size,lymph node status,clinical TNM stage and the expression levels of CerbB-2（P 0.05）,while they showed no correlation with the expression levels of ER and PR（P 0.05）.[Conclusion] SDI of diffused optical tomography with ultrasonography is closely related to microvessel density in breast cancer,which can indirectly reflect the angiogenic activity.It also might play a great role of early diagnosis and in distinguishing benign and malignant tumors.

关 键 词：超声光散射断层成像系统 乳腺癌 综合诊断指数 微血管密度 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]