顺铂联合白介素-2治疗恶性胸腔积液的疗效观察  

Clinical observations on thoracic closed drainage combined with cisplatin and IL-2 for pleural effusion of pulmonary carcinoma

作　　者：邱艳 周晓蕾[2] 吴志强[2] 曹瑛 

机构地区：[1]信阳市第五人民医院呼吸内科,河南信阳464000 [2]郑州大学第一附属医院,河南郑州450052

出　　处：《河南医学研究》2011年第3期283-285,共3页Henan Medical Research

摘　　要：目的:观察胸膜腔灌注顺铂联合白介素-2治疗肺癌患者恶性胸腔积液的临床疗效和毒副反应。方法:将76例肺癌并恶性胸腔积液患者随机分成治疗组和对照组。治疗组41例,联合应用顺铂及白介素-2进行胸膜腔灌注治疗;对照组35例,单用顺铂进行胸膜腔灌注治疗。两组每周用药1次,连用3周后判断临床治疗效果。结果:治疗组完全缓解12例,部分缓解24例,稳定3例,进展2例,有效率87.80%;而对照组完全缓解7例,部分缓解11例,稳定4例,进展13例,有效率51.43%。比较两组临床疗效差异,χ2=12.41,P<0.05,差异有统计学意义。毒副反应主要是Ⅰ～Ⅱ度胸痛、发热、恶心呕吐和白细胞减少。结论:胸膜腔灌注顺铂联合白介素-2治疗肺癌恶性胸腔积液临床疗效显著,明显优于单用顺铂胸膜腔灌注治疗,且不良反应轻。Objective：To observe the clinical efficacy and side effects of infusing the combination of cisplatin and interleukin-2 to pleural cavity in the treatment of lung cancer patients with malignant pleural.Methods：76 cases of lung cancer with malignant pleural effusion were randomly divided into treatment groups and control groups.There were 41 patients in treatment groups,to be treated by infusing the combination of cisplatin and interleukin-2 to pleural cavity;there were 35 patients in control groups,with the treatment of pleural perfusion with cisplatin.Infusion therapy once a week to two groups,and the therapeutic efficacy was evaluated after three weeks.Results：In the treatment groups,control response（CR） was 12,partial response（PR） was 24,stable disease（SD） was 3,progressive disease（PD） was 2,efficiency was 87.80%;and in the control groups,CR was 7,PR was 11,SD was 4,PD was 13,efficiency was 51.43%.The efficacy of the two groups was compared.Results the efficacy of the two groups had significance（χ2=12.41,P 0.05）.The mainly side effects were,Ⅰ～Ⅱ degree of chest pain,fever,nausea,vomiting, and leucopenia.Conclusion：Infusing the combination of cisplatin and interleukin-2 to pleural cavity in the treatment of lung cancer patients with malignant pleural has the significant efficacy,significantly better than the perfusion with cisplatin,and relieving side effects adverse reactions.

关 键 词：胸膜腔灌注 顺铂 白介素-2 肺癌 

分 类 号：R734[医药卫生—肿瘤]