Tolerance of nestin^+ cholinergic neurons in the basal forebrain against colchicine-induced cytotoxicity  

作　　者：Jing Yu Kaihua Guo Dongpei Li Jinhai Duan Juntao Zou Junhua Yang Zhibin Yao 

机构地区：[1]Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou-510080, Guangdong Province, China [2]East Department of Neurology, Guangdong General Hospital, Guangdong Institute of Geriatrics, Guangzhou 510080, Guangdong Province China

出　　处：《Neural Regeneration Research》2011年第24期1860-1864,共5页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China,No. 30700436

摘　　要：In the present study we injected colchicine into the lateral ventricle of Sprague-Dawley rats to investigate the effects of colchicine on the number of different-type neurons in the basal forebrain and to search for neurons resistant to injury. After colchicine injection, the number of nestin^＋ cholinergic neurons was decreased at 1 day, but increased at 3 days and peaked at 14-28 days. The quantity of nestincholinergic neurons, parvalbumin-positive neurons and choline acetyl transferase-positive neurons decreased gradually. Our results indicate that nestin^＋ cholinergic neurons possess better tolerance to colchicine-induced neurotoxicity.In the present study we injected colchicine into the lateral ventricle of Sprague-Dawley rats to investigate the effects of colchicine on the number of different-type neurons in the basal forebrain and to search for neurons resistant to injury. After colchicine injection, the number of nestin^＋ cholinergic neurons was decreased at 1 day, but increased at 3 days and peaked at 14-28 days. The quantity of nestincholinergic neurons, parvalbumin-positive neurons and choline acetyl transferase-positive neurons decreased gradually. Our results indicate that nestin^＋ cholinergic neurons possess better tolerance to colchicine-induced neurotoxicity.

关 键 词：COLCHICINE basal forebrain choline acetyl transferase nestin PARVALBUMIN 

分 类 号：S565.4[农业科学—作物学] TB53[理学—物理]