小剂量地塞米松对颞叶癫痫雄性大鼠脑电图的影响  

Influence of low-dose dexamethasone on electroencephalogram in temporal lobe epileptic male rats

作　　者：梁建民[1] 李淞[2] 李秀杰[1] 张淑琴[3] 李海波[1] 

机构地区：[1]吉林大学第一医院儿科,吉林长春130021 [2]吉林省人民医院神经内科,吉林长春130021 [3]吉林大学第一医院神经内科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2011年第5期797-800,共4页Journal of Jilin University：Medicine Edition

基　　金：中国博士后基金资助课题(2005037033);吉林省科技厅自然科学基金资助课题(201015147);吉林省长春市科技局儿科诊疗中心重点专科建设项目资助课题(2010120)

摘　　要：目的:探讨小剂量地塞米松对颞叶癫痫雄性大鼠顶叶皮层脑电图的影响,为糖皮质激素相关药物治疗颞叶癫痫提供依据。方法:雄性Wistar大鼠随机分为正常组、假手术组、生理盐水预处理后颞叶癫痫点燃对照组(NS-control组)和小剂量地塞米松短期预处理后颞叶癫痫点燃组(Dex组),颞叶癫痫点燃模型采用海人酸杏仁核微量注射方法建立,记录正常组和假手术组大鼠顶叶皮层脑电图并连续观察NS-control组和Dex组癫痫点燃后6 h大鼠脑电图变化。结果:与NS-control组比较,Dex组大鼠癫痫点燃潜伏期延长(P<0.05),6 h总放电持续时间缩短(P<0.05),波幅降低(P<0.05)。结论:小剂量地塞米松对雄性大鼠颞叶癫痫放电存在抑制作用,提示其可能对治疗颞叶癫痫有效。Objective To explore the influence of low-dose dexamethasone（Dex） on the electroencephalogram（EEG） in temporal lobe epileptic male rats,and provide basis for glucocorticoid-related drugs in treatment of temproal lobe epilepsy.Methods Wistar rats were randomly divided into normal group,sham group,control group kindled with temporal lobe epilepsy after pretreated with normal saline（NS-control group） and observation group kindled with temporal lobe epilepsy pretreated with low-dose Dex（Dex group）.The temporal lobe epileptic model was established via kainic acid（KA） microinjected（1 μg） into right nucleus amygdalae of male Wistar rats.EEG on parietal lobe cortex was recorded in normal group and sham group,and EEG was monitored successively for 6 h after KA kindling in NS-control group and Dex group.Results Compared with NS-control group,the kindling latency of temporal lobe epilepsy was delayed in Dex group（P0.05）,the total lasting time of seizure discharge within 6 h was shorten（P0.05）,and the amplitude of EEG wave was significantly decreased（P0.05）.Conclusion Low-dose Dex may inhibit the epileptic discharge in temporal lobe epileptic male rats,and it indicates that low-dose Dex may be effective for curing temporal lobe epilepsy.

关 键 词：地塞米松 癫痫 海人酸 点燃 脑电图 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]