脑源性神经营养因子及其受体TrkB和p75NTR在隆突性皮肤纤维肉瘤和皮肤纤维瘤中的表达  

Expression of BDNF and its receptors TrkB and p75NTR in dermatofibrosarcoma protuberans and dermatofibroma

作　　者：钱悦[1] 张娜[1] 褚淑娟[1] 冯爱平[1] 陈思远[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院,武汉430022

出　　处：《中国麻风皮肤病杂志》2011年第9期601-604,共4页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金资助项目(编号:30600535)

摘　　要：目的:确定脑源性神经营养因子(BDNF)及其受体TrkB、p75NTR在隆突性皮肤纤维肉瘤和皮肤纤维瘤中的表达。方法:应用免疫组化ABC法对隆突性皮肤纤维肉瘤石蜡标本17例、皮肤纤维瘤石蜡标本15例,检测BDNF及其受体TrkB、p75NTR的表达。结果:BDNF及其受体TrkB、p75NTR在隆突性皮肤纤维肉瘤中的表达显著高于皮肤纤维瘤中的表达(P<0.01);BDNF与TrkB、p75NTR在隆突性皮肤纤维肉瘤中的表达呈正相关(P<0.01)。结论:BDNF通过其受体TrkB以及p75NTR在隆突性皮肤纤维肉瘤的发病机制中可能起着一定的作用。Objective： To investigate the potential contribution of brain derived neurophic factor （BDNF） and its receptors TrkB and p75NTR in the development of dermatofibrosarcoma protuberans （DFSP）. Methods： Seventeen paraffin - embedded DFSP specimens and 15 paranembedded dermatofibroma were subjected to immunohistochemical staining for BDNF, TrkB and p75NTR. Results： The expression of BDNF and TrkB was significantly higher inl7 DFSP than in 15 dermatofibroma （ P 〈 0.01）. The expression of BDNF, TrkB and p75NTR in DFSP was positively correlated. Conclusions： The results indicate that overexpression of BDNF, TrkB and p75NTR may play a role in the develonment of DFSP.

关 键 词：隆突性皮肤纤维肉瘤 皮肤纤维瘤 脑源性神经营养因子 

分 类 号：R739.5[医药卫生—肿瘤]