Endocrine milieu and erectile dysfunction： is oestradio-testosterone imbalance, a risk factor in the elderly？  

作　　者：Balasubramanian Srilatha P Ganesan Adaikan 

机构地区：[1]Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University Hospita National University of Singapore, NUHS Tower Block, 1E Kent Ridge Road, 119228, Singapore

出　　处：《Asian Journal of Andrology》2011年第4期569-573,共5页亚洲男性学杂志（英文版）

摘　　要：Oestrogens are not exclusive to the female gender but occur in moderate circulating levels of 25-70 pg ml^-1 in men, compared to 44- 153 pg ml^-1 in women. Arising from aromatisation of testosterone （T）, oestrogen is considered to have many opposing physiological functions and the progressive T decline in the aging male is associated with relative and/or absolute increase in serum oestradiol （E2）. Sexual disinterest and erectile dysfunction （ED） in the elderly may well be due to pathophysiological E2-T imbalance; the altered hormonal ratio may also explain the higher incidence of ED in hyperestrogenism or following exposure to environmental/plant oestrogens.Oestrogens are not exclusive to the female gender but occur in moderate circulating levels of 25-70 pg ml^-1 in men, compared to 44- 153 pg ml^-1 in women. Arising from aromatisation of testosterone （T）, oestrogen is considered to have many opposing physiological functions and the progressive T decline in the aging male is associated with relative and/or absolute increase in serum oestradiol （E2）. Sexual disinterest and erectile dysfunction （ED） in the elderly may well be due to pathophysiological E2-T imbalance; the altered hormonal ratio may also explain the higher incidence of ED in hyperestrogenism or following exposure to environmental/plant oestrogens.

关 键 词：aging erectile dysfunction hormone imbalance OESTRADIOL PHYTOESTROGEN TESTOSTERONE 

分 类 号：Q579.11[生物学—生物化学] TQ463[化学工程—制药化工]