血清GP73、AFP和AFP-L3联合检测在原发性肝癌诊断中的价值  

Significance of serum golgi protein 73 （ GP73 ）, alpha-fetoprotein （ AFP ） and lectin-reactive alpha- fetoprotein （AFP-L3） expresssion in primary hepatic carcinoma

作　　者：许文芳[1] 费迎明[1] 周建康[1] 沈华江[1] 陈雪芳[1] 吕秋琼[1] 丁予昀[1] 

机构地区：[1]绍兴市第六人民医院检验科,浙江312000

出　　处：《中华实验和临床病毒学杂志》2011年第4期286-288,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的 探讨血清中高尔基体蛋白73（ GP73）、甲胎蛋白（AFP）和甲胎蛋白异质体（AFP-L3）单独和联合检测对原发性肝癌（PHC）诊断的意义，为PHC诊断和普查提供一种新方法。方法采用ELISA对81例PHC、176例慢性肝炎和肝硬化、30例其他肿瘤疾病和40名健康人的血清GP73、甲胎蛋白异质体（ AFP-L3）和AFP进行检测。结果 GP73、AFP和AFP-L3在肝癌组的敏感度分别为77.78％、62.69％和51.85％，在非肝癌组的特异性分别为84.55％、86.99％和96.34％。三者联合检测时，其诊断的敏感度可提高至88.89％。结论 GP73对PHC诊断具有较好的敏感度，AFP-L3具有较高的特异性。血清GP73、AFP和AFP-L3联合检测可有效提高PHC的临床诊断效果。Objective To explore the alone and joint diagnostic value of serum golgi protein 73 （GP73）, alpha-fetoprotein （ AFP） and the percentage of lectin-reactive alpha-fetoprotein （ AFP-L3 ） of primary hepatic carcinoma （PHC） ,and provide a novel method for diagnosis for PHC and screening for highrisk population. Methods ELISA was used to detect the serum level of GP73, AFP and AFP-L3% in 81 cases of PHC, 176 cases chronic hepatitis and liver cirrhosis , 30 cases other tumber cancer and 40 cases of health people. Results The sensitivity of GP73, AFP and AFP-L3% in PHC is 77.78% ,62.69% and 51.85% ,and the specificity is 84. 55% ,86. 99% and 96. 34% ,respectively. Joint detection could increase the sensitivity up to 88.89%. Conclusion GP73 was a high sensitivity mark for dignosis of PHC, while AFP-L3% was a high specificity mark for dignosis of PHC. The joint detection could improve PHC diagnostic performance.

关 键 词：肝肿瘤 癌 肝细胞 高尔基体 甲胎蛋白类 

分 类 号：R735.7[医药卫生—肿瘤]