超声造影在早期肝硬化诊断中的应用  

Use of contrast-enhanced ultrasound in diagnosis of early hepatic cirrhosis

作　　者：乔英艳[1] 王兴华[1] 雷成功[1] 夏国昌[1] 石颖[1] 王芹秀[1] 

机构地区：[1]山西医科大学第二医院超声科,太原030001

出　　处：《中国药物与临床》2011年第10期1127-1129,共3页Chinese Remedies & Clinics

基　　金：山西省科技攻关项目(20100311096-2)

摘　　要：目的评估应用超声造影定量评价早期肝硬化的临床价值。方法试验分组:健康对照组20名,肝硬化组30例。超声造影观察肝动脉、门静脉、肝静脉及肝实质的显影动态过程,应用造影分析软件(QLAB时间-强度曲线)定量分析,得到定量参数,包括有肝动脉、门静脉、肝静脉及肝实质开始显影时间及达峰值时间。并计算出肝动脉-肝静脉渡越时间(HA-HVTT)、门静脉-肝静脉渡越时间(PV-HVTT)。结果肝静脉开始显影时间肝硬化组较健康对照组显著缩短(P<0.01);HA-HVTT及PV-HVTT肝硬化组较健康对照组显著缩短(P<0.01);肝实质达峰值时间肝硬化组较健康对照组显著延长(P<0.05)。结论肝静脉开始显影时间、肝脏渡越时间及肝实质达峰值时间等参数可作为无创诊断早期肝硬化的定量指标。Objective To explore the clinical value of contrast-enhanced ultrasound（CEUS） in quantitative evaluation of early hepatic cirrhosis.Methods Two groups of subjects,one as the control group（n=20） and the other consisting of patients with early hepatic cirrhosis（n=30）,were recruited.The subjects were examined with CEUS to study dynamic visualization of hepatic artery,portal vein,hepatic vein and liver parenchyma.The whole enhancement process was analyzed by QLAB time-intensity curves software to collect the data for quantitative analysis,which included arriving time（AT） and peak time（PT） of hepatic artery,hepatic vein,portal vein and liver parenchyma.The hepatic artery to hepatic vein transit time（HA-HVTT） and the portal vein to hepatic vein transit time（PV-HVTT） were then calculated.Results The patients with hepatic cirrhosis showed significantly shorter arriving time of hepatic vein（HVAT）,HA-HVTT and PV-HVTT（all P0.01）,and longer peak time of liver parenchyma as compared with the control group（P0.05）.Conclusion HVAT,HA-HVTT,PV-HVTT and the peak time of liver parenchyma can be used in non-invasive diagnosis of early hepatic cirrhosis.

关 键 词：造影剂 肝硬化 超声检查 

分 类 号：R575.2[医药卫生—消化系统]