两种定量检测甲胎蛋白与癌胚抗原的方法比较  

Comparison of two quantitative measurement on detection of alpha-fetoprotein and carcinoembryonic antigen

作　　者：石艳芬[1] 郑小霞[1] 陈源清[1] 

机构地区：[1]福建省龙岩市第二医院检验科,364000

出　　处：《检验医学与临床》2011年第19期2319-2319,2321,共2页Laboratory Medicine and Clinic

摘　　要：目的对两种不同方法检测甲胎蛋白(AFP)与癌胚抗原(CEA)的重复性及检测结果的差异进行方法学对比和偏倚评估,探讨不同分析方法检测结果是否具有可比性及偏倚是否在允许范围内。方法以可溯源的罗氏电化学发光法检测结果为比较方法,以时间分辨法检测结果为实验方法。结果经F检验,两种仪器检测甲胎蛋白与癌胚抗原的差异无统计学意义(P>0.05),偏倚均在允许范围。结论两种仪器性能稳定,重复性佳,相关性良好,结果具有可比性,在临床中可同时或交替使用。Objective To compare the repeatability,test result and bias estimation of two methods on detection of alpha-fetoprotein（AFP） and carcinoembryonic antigen（CEA）,and explore whether the test results of different analysis methods are comparable and the bias is within the allowable range.Methods We took the traceable Roche electrochemiluminescence detection method for comparing the results of time-resolved detection of the experimental method.Results The result of two detection equipments on AFP and CEA analyzed by the F test was not significantly different（P0.05）,with the allowable bias.Conclusion The two kinds of instruments have good performance and stability,good reproducibility and correlation,which could be used simultaneously or alternatively in clinic.

关 键 词：甲胎蛋白 癌胚抗原 电化学 发光测定法 时间分辨 偏倚 

分 类 号：R734.2[医药卫生—肿瘤]