盐酸巴尼地平β-环糊精包合物的制备  

Preparation of Barnidipine Hydrochloride-β-Cyclodextrin Inclusion Complexation

作　　者：李艳[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《医药导报》2011年第10期1335-1337,共3页Herald of Medicine

摘　　要：目的研究盐酸巴尼地平(barnidipine hydrochloride,BN)β-环糊精(β-cyclodextrin,β-CD)包合物的最佳制备工艺。方法采用饱和水溶液法制备盐酸巴尼地平环糊精(BN-β-CD)包合物,采用正交实验设计法,以载药量和包合率为评价指标,确定优化制备工艺条件。结果最佳工艺条件为:盐酸巴尼地平与β-CD的投料摩尔比为1∶2,搅拌速度为200 r.min-1,包合温度70℃,包合时间2 h。结论该法可用于盐酸巴尼地平β-CD包合物的制备,盐酸巴尼地平的溶解度在包合物中得到显著提高。Objective To study the optimum preparation technology for barnidipine hydrochloride-β-cyclodextrin（BN-β-CD） inclusion complexation. Methods Saturated aqueous solution method was used to prepare BN-β-CD inclusion complexation,orthogonal design was carried out to optimize the preparation technology by taking the drug loading capacity and inclusion efficiency as the evaluation index. Results The preparation conditions were optimized by orthogonal experiment as follows： barnidipine hydrochloride： β-cyclodextrin being 1：2,stirring speed was 200 r·min-1,inclusion temperature at 70 ℃,mixing time as 2 h. Conclusion The method can be used for preparation of BN-β-CD inclusion complexation,in which the dissolution rate of the inclusion complex made by the optimized preparation process increased significantly.

关 键 词：巴尼地平 盐酸 Β-环糊精 包合物 正交实验 

分 类 号：R972.4[医药卫生—药品] TQ460.6[医药卫生—药学]