Flt-1和MVD在乳腺癌组织中的表达及意义  

Expression and pathological significance of Flt-1 and MVD in human breast cancer

作　　者：余海浪[1] 马文丽[1] 周珏宇[1] 刘安玲[1] 郑文岭[2] 

机构地区：[1]南方医科大学基因工程研究所,广东广州510515 [2]华南基因组中心,广东广州510800

出　　处：《中国现代医学杂志》2011年第25期3129-3131,3136,共4页China Journal of Modern Medicine

基　　金：广东省重点实验室建设经费资助(No:2004B60144);国家自然科学基金资助项目(No:30900555)

摘　　要：目的研究血管内皮生长因子受体1(Flt-1)和微血管密度(M VD)在乳腺癌组织中的表达及其意义。方法采用免疫组织化学染色SP法检测56例乳腺癌组织和32例癌旁正常组织中Flt-1和M VD的表达,分析其与乳腺癌临床病理特征间的联系。结果 Flt-1在乳腺癌中的阳性表达率和M VD值分别为75.0%和(44.76±10.17),显著高于癌旁正常组织的12.5%和(10.29±2.38)(P<0.05),且与乳腺癌的临床分期及淋巴结的转移有关,与病理类型、组织分型及ER、PR无关。乳腺癌组织中Flt-1与M VD的表达呈正相关(r=0.72,P<0.01)。结论 Flt-1在乳腺癌组织中高表达,尤其在伴有淋巴转移的癌组织中表达增高。Flt-1的高表达与M VD值的升高可作为乳腺癌的生长、转移以及预后的重要判定指标。【Objective】 To investigate the expression and significance of Flt-1 and MVD（microvessel density） in breast cancer.【Methods】 The expression of Flt-1 and MVD in 56 breast cancer and 32 paracarcinoma specimens resected from patients were examined by immunohistochemistry（SP） staining method.The relationship between their expression and the clinicopathological features of breast cancer was analyzed.【Results】 The positive expression rate of Flt-1 and MVD value in breast cancer were 75% and（44.76±10.17）,respectively,which were significantly higher than those in paracarcinoma tissues [12.5%,（10.29±2.38）;P 0.05],and the expression of those were associated with clinical stage and lymph node metastasis in breast cancer（P 0.05）,but not pathological type,differentiation degree,ER and PR.Additionally,the expression of Flt-1 and MVD were positively correlated in breast cancer（r =0.72,P 0.01）.【Conclusions】 Flt-1 is over-expressed in breast cancer tissues,especially tissues with lymph node metastasis.The expression of Flt-1 and MVD might be significantly correlated with growth,invasion and metastasis of breast cancer.

关 键 词：FLT-1 MVD 乳腺癌 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]