转突触示踪技术与伤害性感受相关中枢核团研究进展  

Progress of transynaptic tracing and nociception-related central nucleus

作　　者：谢晓莉[1] 李国才[2] 石永勇[2] 贺嵩敏[3] 项红兵（综述） 蔡红伟（审校）[1] 

机构地区：[1]中南大学湘雅医院口腔科,湖南长沙410008 [2]广东省中医院麻醉科,广东广州510120 [3]广东省中医院药理实验室,广东广州510120 [4]Oregon Health ＆ Sciences University, Portland, Oregan, 97201, USA

出　　处：《中国现代医学杂志》2011年第25期3148-3152,共5页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:81071307)

摘　　要：伤害性感受是通过交感和运动神经来接受中枢神经系统的调控。最近推出的有关伤害性感受相关中枢核团的研究进展。表现在:运用能够表达独特标记蛋白的伪狂犬病毒重组体来进行多突触示踪,以及开发在独特启动子调控下能够表达荧光蛋白的转基因小鼠作为研究工具。该文就转突触示踪技术与伤害性感受相关中枢核团的研究进展进行综述。The neural control of nociception is exerted by the central nervous system via sympathetic and motor nerve.Some recently introduced improvement in chronic nociception-related central nucleus are transynaptic tracing using isogenic pseudorabies virus recombinants that express unique reporter proteins,as well as generating some transgenic mice line expressing fluorescent protein under the control of special promoter using a modified artificial chromosome.Transynaptic tracing and chronic pain-related central nucleus were reviewed.

关 键 词：伤害性感受 中枢核团 转突触示踪 伪狂犬病毒 荧光蛋白 

分 类 号：R-3[医药卫生]