左卡尼汀治疗复苏后多器官功能障碍综合征的临床观察  

Clinical Observation of Levocarnitine for the Treatment of Postresuscitation Multiorgan Dysfunction Syndrome

作　　者：陈达[1] 王斯闻[1] 朱杰[1] 王绍久[1] 李岭[1] 

机构地区：[1]中国医科大学附属第四医院急诊科,辽宁沈阳110032

出　　处：《医学临床研究》2011年第9期1639-1641,共3页Journal of Clinical Research

基　　金：辽宁省科学技术基金项目（2009225040）

摘　　要：[目的]观察左卡尼汀治疗复苏后多器官功能障碍综合征的临床疗效.[方法]60例复苏后多器官功能障碍综合征患者随机分为两组,对照组30例,采用常规治疗;治疗组30例,在常规治疗的基础上加用静脉注射左卡尼汀.观察两组治疗后1、3天血清肿瘤坏死因子-a、白细胞介素-1、白细胞介素-6的水平.[结果]治疗组血清肿瘤坏死因子-α、白细胞介素-1、白细胞介素-6下降均显著优于对照组（P〈0.05）,治疗组的生存率较对照组明显提高（P〈0.01）,治疗组住ICU的时间也比对照组明显缩短（P〈0.01）.[结论]左卡尼汀治疗复苏后多器官功能障碍综合征疗效较好,可用于复苏后多器官功能障碍综合征的治疗.[Objective]To observe the clinical efficacy of levocarnitine for the treatment of postresuscitation multiorgan dysfunction syndrome（PR-MODS）. [Methods] Sixty patients with PR-MODS were randomly divided into two groups. The control group（ n =30） was given routine therapy. The treatment group was given routine therapy in combination with levocarnitine through intravenous injection. The levels of serum tumor necrosis-alpha（TNF-α）, interleukin-1（IL-1） and interleukin-6（IL-6） at 1 and 3 days after the treatment were compared between two groups. [Results] The levels of TNF-α, IL-1 and IL-6 in the treatment group were sig- nificantly lower than those in the control group（ P 〈0.05）. The survival rate in the treatment group was significantly higher than that in the control group（ P 〈0.01）. Moreover, the total time in ICU in the treatment group was obviously shorter than that in the control group（ P 〈0.01）. [Conclusion] Levocarnitine for treating PR-MODS has good effect, so it can be used in the treatment of PR-MODS.

关 键 词：多器官功能衰竭/药物疗法 肉碱/治疗应用 

分 类 号：R365[医药卫生—病理学]