氯诺昔康防治瑞芬太尼所致痛觉过敏现象的临床观察  

Clinical Observation of the Efficacy of Lornoxicam for the Prevention and Cure of Hyperalgesia After Remifentanil-based Anesthesia

作　　者：莫洪[1] 贺亮[2] 

机构地区：[1]湖南省常德市第一人民医院麻醉科,湖南常德415000 [2]湖南省娄底市中心医院麻醉科,湖南娄底417000

出　　处：《医学临床研究》2011年第9期1714-1716,共3页Journal of Clinical Research

摘　　要：[目的]探讨氯诺昔康对瑞芬太尼痛觉过敏现象的防治作用.[方法]选择因甲状腺肿块行择期手术患者40例,随机分为A、B两组（n=20）,A组在诱导前予以氯诺昔康16 mg,B组在诱导前予以生理盐水5 mL.观察比较两组在PACU的躁动情况及注药前（T1）,清醒后30 min（T2）,1 h（T3）,2 h（T4）,4 h（T5）,6 h（T6）6个时点的VAS评分.[结果]A组术后躁动发生率低于B组,其差异有显著意义（P〈0.05）;A组VAS评分在清醒后2 h内低于B组,其差异有显著意义（P〈0.05）,2 h后两组VAS评分相比较无显著差异.[结论]氯诺昔康能有效防治持续泵注瑞芬太尼所致的痛觉过敏现象.[Objective] To explore the effect of lornoxicam for the prevention and cure of hyperalgesia after remifentanil-based anesthesia. [Methods] Forty patients scheduled for thyroidectomy were randomly divided into group A（ n =20） and group B（ n =20）. Group A was given iornoxicam 16mg before the anesthesia in duction, while group B was given normal saline 5mL before the anesthesia induction. The restlessness at postanesthetic ICU（PACU） and visual analogue scale（VAS） score before administration（T1 ）, 30min（T2 ）, lh （T3）, 2h（T4 ）, 4h（T5 ） and 6h（T6 ） after consciousness were observed and compared between two groups. [Results] The incidence of restlessness after operation in group A was lower than that in group B, and there was significant difference（ P 〈0.05）. VAS score in group A at 2h after consciousness was lower than that in group B, and there was significant difference（ P 〈0.05）. There was no significant difference in VAS score at 2h after consciousness between two groups. [Conclusion] Lornoxicam can effectively prevent and cure hyperalgesia after remifentanil based anesthesia.

关 键 词：痛觉过敏/预防和控制 芬太尼/副作用 氧化还原酶类/治疗应用 

分 类 号：R741[医药卫生—神经病学与精神病学]