甘氨双唑钠对食管癌放疗增敏作用的临床观察  

The clinical study of CMNa on radiosensitivity-enhanced effect treating esophageal cancer

作　　者：王明智[1] 吴伟[1] 吴刚[1] 王震吾[1] 张晓军[1] 周嘉梁[1] 

机构地区：[1]苏州大学附属第四医院肿瘤科,214062

出　　处：《中国现代医药杂志》2011年第10期63-65,共3页Modern Medicine Journal of China

摘　　要：目的探讨单纯适形放疗与适形放疗联合希美钠(CMNa)治疗食管癌的疗效。方法 81例食管癌患者随机分为单纯放疗组(对照组)与放疗加希美钠组(治疗组)。放疗剂量均为DT66Gy/30次,5次/周,治疗组加用希美钠800mg/m2滴注,每周3次,隔天静脉滴注,30min滴完。结果对照组:CR24.3%,PR65.8%,总有效率90.1%。治疗组:CR60.0%,PR37.5%,总有效率97.5%,两组CR比较疗效有显著差异(P<0.05),总有效率比较疗效无显著差异(P>0.05)。结论两组治疗方式对食管癌疗效无显著差异,但使用甘氨双唑钠组CR率更高。Objective To discuss clinical effect of single 3 dimensional confomal radiation therapy and combined with CMNa in the treatment of esophageal cancer. Methods 81 patients with esophageal cancer were divided into two groups randomly：single radiotherapy group（comparison group） and radiotherapy plus CMNa injection group（therapy group）. Both radiothera- py dosage were DT 66Gy/33Fx, 5 times/week. CMNa 800mg/m2,3 times/week,was injected within 30 minutes in the therapy group. Results Comparison group：CR 24.3%, PR 65.8%, total efficiency 90.1%. Therapy group：CR 60.0%, PR 37.5%, total efficiency 97.5%, The total efficiency of two groups had no obvious difference （P〉0.05）. The CR of two groups had obvious difference （P〈0.05）. Conclusion The therapy methods between the two groups had no obvious difference in increasing the survival rates, but it worked rapidly after plus CMNa injection, also the rate of CR maybe higher.

关 键 词：食管癌 三维适形放疗 希美钠 放射敏感性 

分 类 号：R735.1[医药卫生—肿瘤]