粪便隐血免疫双联法在服用小剂量肠溶阿司匹林致消化道出血中的应用研究  

To investigate the application of dejeeta occult blood with hemoglobin and/or transferrin monoclonal immunoassay on gastrointestinal bleeding induced by taking low-dose ASA

作　　者：章金灿[1] 郑大明[1] 许贤彬[1] 陆卫歆[1] 杨燕珠[1] 苏锦霞[1] 

机构地区：[1]潮州市中心医院,521021

出　　处：《国际医药卫生导报》2011年第20期2536-2538,共3页International Medicine and Health Guidance News

摘　　要：目的探讨粪便隐血免疫双联法在监测服用小剂量肠溶阿司匹林（ASA）致消化道出血中的应用价值。方法对328例需长期服用小剂量ASA的患者和对照组30例，要求不服用口服抗凝剂、无消化道出血征象的心脑血管疾病患者，分别于服药前、服用1周、1个月、3个月、6个月应用隐血免疫双联法（血红蛋白免疫法和转铁蛋白免疫法）检测粪便隐血，阳性者再行胃镜检查，确定上消化道出血与否。结果①治疗组328例检出粪便隐血免疫双联法阳性40例，阳性率（12．2％），与对照组（3．3％）比较，差异有显著性（P〈0．05）；②治疗组粪便隐血免疫双联法阳性40例中行胃镜检查29例，示病理意义24例，另外5例的粪便隐血血红蛋白免疫法及转铁蛋白免疫法却都阳性；③治疗组粪便隐血免疫双联法阳性40例的出血监测时间差异无显著性（P〉0．05）。结论可以常规应用粪便隐血免疫双联法监测长期服用小剂量ASA引起的消化道出血。Objective To explore the application value of dejecta occult blood coupled with hemoglobin and/or transferrin monoclonal immunoassay on inspect gastrointestinal bleeding induced by taking low-dose ASA. Methods 328 cases taking low-dose ASA in long-time were set as therapy group; 30 cases patients with Heart-Brain vas disease not taking ASA and not having the sign of gastrointestinal bleeding were set as control group. Detected dejecta occult blood with hemoglobin and/or transferrin monoclonal immunoassay 1 week, 1 month, 3 months, 6 months before taking medicine. Took Gastroscopy if dejecta occult blood were positive to see if upper gastrointestinal were bleeding or not. Results （1） Among these 328 patients, dejecta occult blood was detected with hemoglobin and/or transferrin monoclonal immunoassay; 40 cases were positive（ 12.2% ）in therapy group, while control group had 1 case（3.3%,1/ 30）;there was statistical difference （ P 〈 0.05 ）. （2） There were 29 cases taking Gastroscopy of 40 cases whose dejecta occult blood was positive; 24 cases had pathology significance; hemoglobin and transferrin monoclonal immunoassay was positive of the other 5 cases. （3）Fhere was no statistical significant difference on bleeding time （P〉 0.05 ）. Conclusion Dejecta occult blood detected with hemoglobin and/or transferrin monoclonal immunoassay could be a routine inspection for gastrointestinal bleeding induced by taking low-dose ASA in long-time.

关 键 词：胃肠出血 阿司匹林 血红蛋白 转铁蛋白 胃镜检查 

分 类 号：R57[医药卫生—消化系统]