豆根管食通口服液对食管癌患者近期生活质量的影响  

Effects of Dougen GuanShi Tong oral to the recently life quality esophageal cancer patients

作　　者：姬卫国[1] 

机构地区：[1]河南中医学院第三附属医院,河南郑州450008

出　　处：《中医临床研究》2011年第18期1-4,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:通过国际通用的生活质量量表评估豆根管食通口服液对中晚期食管癌患者生活质量的影响。方法:采用随机、对照的方法,临床观察了60例符合纳入标准的食管癌患者,分为对照组和治疗组,各30例。治疗组口服"豆根管食通口服液"治疗,每天三次,每次一支(10ml,1g/ml),一个月为一个疗程,共两个疗程;对照组口服替加氟,每天四次,每次4片(200mg),一个月为一个疗程,共两个疗程。治疗前、第一及第二疗程后分别测一次生活质量,量表采用欧洲癌症研究与治疗组织生活质量核心量表QLQ-C3(0V3.0)中文版进行问卷调查并行记分评定。统计采用SPSS11.0统计软件,计算所有数据以均数±标准差(x±s)表示。结果:豆根管食通口服液组在1疗程、2疗程后总体健康状况、各功能项目及绝大部分症状单项分别较前有明显改善,差异有显著性(P<0.05);而对照组对生活质量各个领域均无明显改善,差异无显著性(P>0.05),且腹泻(DI)项在治疗1、2疗程后与治疗前相比得分明显提高(症状加重),差异具有显著性(P<0.05);组间比较,除个别症状单项因治疗前基础得分较低,治疗后得分减少不明显外,其余各项在1疗程、2疗程后对比具有显著性差异(P<0.05)。结论:豆根管食通口服液能有效改善食管癌患者的生活质量。Objective：Evaluating the effects of Dougen GuanShi Tong oral to the recently life quality esophageal cancer patients through internationally accepted life quality scale.Methods：Appling randomized,controlled approach,observed 60 cases and divided them into control group and treatment group,each group with 30 cases.The treatment group treated with Dougen GuanShi Tong oral,three times a day,took one each time（10ml,1g/ml）,one month as a course,a total of two courses.The control group treated with tegafur,four times a day,each time took four pills（200mg）,one month as a course,a total of two courses.Measuring life quality before treatment,after the first course treatment and the second course treatment,scale applied european cancer research and treatment organizational life quality core scale QLQ-C30（V3.0）Chinese version to do the survey and points assessment.Using SPSS11.0 statistical software,calculated all data and expressed it by（x±s）.Results：All aspects of the treatment group received significantly change,there was a significant difference （P〈0.05）,while there was no significantly difference of control group（P〉0.05）,and diarrhea（DI）items were significantly improved （symptoms aggravation）,had significant difference（P〈0.05）,between the two groups,in addition to individual symptoms due to low score before treatment,other items at the first course and the second course had significant difference（P〈0.05）.Conclusion：Dougen GuanShi Tong oral can effectively improve the life quality of patients with esophageal cancer.

关 键 词：食管癌 豆根管食通口服液 生活质量 EORTCQLQ-C30量表 

分 类 号：R735.1[医药卫生—肿瘤]