粪便钙卫蛋白对溃疡性结肠炎的诊断及预测复发的价值  

Research about the diagnostic and predictive value of fecal calprotectin in ulcerative colitis

作　　者：沈姞[1] 李俊霞[1] 王化虹[1] 谢鹏雁[1] 刘新光[1] 

机构地区：[1]北京大学第一医院消化内科,北京100034

出　　处：《肠外与肠内营养》2011年第5期272-276,共5页Parenteral & Enteral Nutrition

摘　　要：目的:探讨粪便钙卫蛋白在溃疡性结肠炎(UC)诊断和预测复发方面的价值。方法:选取UC病人49例、结肠息肉38例和对照组133例,均行结肠镜检查,于检查前1 d内留取粪便,采用ELISA法测定粪便钙卫蛋白的含量。UC临床分级采用Mayo疾病活动指数(UCAI),评价粪便钙卫蛋白测定作为判断UC活动性的指标,随访UC病人2年内的复发情况,评价粪便钙卫蛋白对UC复发的预测价值。结果:UC组病人活动期粪便钙卫蛋白水平显著高于对照组和息肉组(P<0.01);粪便钙卫蛋白水平与UC活动性、是否达到黏膜愈合及UC的复发显著相关。结论:粪便钙卫蛋白的含量与UC活动度呈正相关,可客观反映UC的炎症活动及黏膜愈合情况,预测UC的复发。Objective ： To investigate the diagnostic and predictive value of fecal calprotectin as a non-invasive approach in patients with ulcerative colitis （UC）. Methods： 49 patients with ulcerative colitis, 38 patients with colon polyps, and 133 normal controls were recruited after colonoseopy. All the patients w asked to collect their stool sample one day before colonoscopy for measuring fecal ealprotectin by an enzyme-linked immunosorbent assay. The disease activity of UC was evaluated according to Mayo disease activity index （UCAI）. UC patients were followed up for recurrence within 2 years. Results： Fecal calprotectin concentration in active UC patients was significantly higher than the normal controls and those with colon polyps （ P 〈 0.01 ）. There was no statistically significant difference between the latter two （P 〉 0.05 ）. Fecal calprotectin level was significantly correlated with the disease activity, mucosal healing and recurrence rate of UC. Conclusion ： The levels of fecal calprotectin can be an objective reflection of UC disease activities and mucosal healing, and can predict the recurrence of UC patients.

关 键 词：溃疡性结肠炎 钙卫蛋白 预测复发 

分 类 号：R574.62[医药卫生—消化系统]