鲍温病和皮肤鳞状细胞癌皮损中ΔNp63的表达  

The Expression of ΔNp63 in Bowen Disease and Cutaneous Squamous Cell Carcinoma

作　　者：杜红霞[1] 吴潞明 刘彤云[1] 郑博文[3] 何黎[1] 李谦 顾华[1] 孙东杰[1] 涂颖[1] 邹勇莉[1] 

机构地区：[1]昆明医学院第一附属医院皮肤科,云南昆明650032 [2]云南省老年病医院皮肤科,云南昆明650032 [3]云南省红十字会医院皮肤科,云南昆明650032

出　　处：《中国皮肤性病学杂志》2011年第10期751-753,共3页The Chinese Journal of Dermatovenereology

基　　金：云南省联合专项基金资助项目(2010CD154)

摘　　要：目的观察ΔNp63在鲍温病和皮肤鳞状细胞癌中的表达情况。方法应用免疫组化Envision法检测10例正常皮肤、30例鲍温病及30例皮肤鳞状细胞癌组织中ΔNp63的表达水平,并对该3组标本ΔNp63的表达水平进行比较。结果在鲍温病的皮损组织中,ΔNp63主要在表皮全层细胞中弥漫性表达;在皮肤鳞状细胞癌中,ΔNp63表达与其分化程度相关(P=0.004),即在高分化鳞状细胞癌中,ΔNp63在癌巢外周基底样细胞表达,在中分化鳞状细胞癌中,ΔNp63在癌巢中有弱弥漫性表达。ΔNp63在鲍温病、皮肤鳞状细胞癌及正常皮肤中的阳性表达率差异有统计学意义(P<0.05);但不同部位的鲍温病和皮肤SCC组组织中,ΔNp63表达差异均无统计学意义(P均>0.05)。结论ΔNp63多考虑是未分化及低分化上皮来源肿瘤的标记物。Objective To observe the expressions of ANp63 in Bowen disease and cutaneous squamous cell carcinoma. Methods With immunohistochemical method, △Np63 in normal skin（n = 10）, Bowen disease （n = 30） and cutaneous squamous cell carcinoma （n = 30） tissues were detected and compared. Results The Bowen diseases showed remarkable expression of △Np63 in all cell layers of epidermis. Different expression pattern was associated with degree of SCC differentiation （P 〈 0. 05 ）. In high differentiated SCC, △Np63 was confined to a ring of basal-like cells surrounding. In moderately differentiated SCC, most cells contained △Np63 and their distribution was diffuse in center of cancer nests. The expression of △Np63 in Bowen disease, cuta- neous squamous cell carcinoma and normal skin showed statistically significance difference （ all P 〈 0.05 ）. Conclusion △Np63 expression may be a valuable immunohistochemical marker for undifferentiated and poorly differentiated tumours of epithelial cell origin.

关 键 词：鲍温病 鳞状细胞癌 皮肤 ΔNp63基因 

分 类 号：R739.5[医药卫生—肿瘤]