乳腺颗粒细胞瘤1例临床病理观察并文献复习  

Granular cell tumor of the breast:a clinicopathologic analysis

作　　者：邓云特[1] 杨庆君[1] 胡志勇[1] 叶红[1] 

机构地区：[1]湖北省天门市第一人民医院病理科,431700

出　　处：《中国误诊学杂志》2011年第29期7059-7061,共3页Chinese Journal of Misdiagnostics

摘　　要：目的探讨乳腺颗粒细胞瘤的临床病理特征、诊断与鉴别诊断。方法对1例乳腺颗粒细胞瘤进行组织形态学、影像学和免疫组化研究,并复习文献。结果左乳内上象限触及2 cm×2 cm质硬包块。瘤细胞体积大,圆形、多边形或梭形,胞浆丰富嗜酸性颗粒状,呈实性巢团或条索状排列,浸润性生长。抗淀粉酶PAS阳性,免疫组化染色瘤细胞S-100、NSE、Vimentin(+),CK、EMA、myoglobin、ER和PR均(-)。结论乳腺颗粒细胞瘤少见,临床、影像学、细胞学和冷冻快速切片均易误诊或漏诊,确诊主要依靠病理组织学和免疫组化标记。Objective To investigate the clinicopathological characteristics,diagnosis and differential diagnosis of granular cell tumor（GCT） of the breast.Methods One case of granular cell tumor of the breast was studied by histopathology,radiological and immunohistochemistry,and the literature was reviewed.Results The tumor was located in the upper inner quadrant of the left breast.The tumor was 2 cm×2 cm in size.Microscopically,the cells was large,round,polygonal to spindle in shape,containing abundant eosinophilic granular cytoplasms.It was diastase resistant and PAS positive,the immunohistochemical analysis showed the positive staining for the S-100 protein,NSE and vimentin and the negative staining for cytokeratin,EMA,myoglobin,estrogen and progesterone receptors.Conclusion Primary GCT of the breast is a rare neoplasm.It is usually misdiagnosed based mainly on the clinical,radiological,cytological or rapid intraoperative frozen specimen findings.The correct diagnosis is dependent on the histopathological and immunohistochemical features.

关 键 词：乳腺肿瘤/病理学 颗粒细胞瘤/病理学 

分 类 号：R737.9[医药卫生—肿瘤]