不同运动量对老年痴呆的防治作用及其机制研究  

Study of Effects and Mechemism of Different Exercise Valume on Senile Dementia

作　　者：刘新霞[1] 赵燕燕[2,3] 刘倩梅 高凤国[5] 陈春生[3] 边静[6] 张秋燕[2] 周艳春[1] 刘丽艳[3] 

机构地区：[1]河北大学基础医学院,保定071000 [2]河北大学医学实验中心,保定071000 [3]河北大学化学与环境科学学院,保定071000 [4]河北省保定市第一中心医院,保定071000 [5]河北省保定市第一医院,保定071000 [6]河北大学计算中心医学部,保定071000

出　　处：《中国中医药现代远程教育》2011年第17期144-146,共3页Chinese Medicine Modern Distance Education of China

基　　金：河北省科技攻关资助项目[No:05276101D-88];河北教育厅科学研究计划项目[No:2009315];河北省卫生厅医学科学研究重点课题计划项目[No:20090570];河北省中医药管理局科研计划课题[No:2008072];保定市科技局科学研究与发展计划项目[No:09ZF010];河北大学首批大学生科技创新项目[No:STCP]

摘　　要：目的考察不同运动量对老年痴呆的防治作用,并初步探讨其作用机制。方法采用被动转笼法对昆明种小鼠进行跑轮训练,训练4周后通过小鼠Morris水迷宫检测小鼠的学习记忆能力;BI-2000图像分析系统检测小鼠的微循环情况;通过耐缺氧实验观察小鼠耐缺氧能力。结果与空白对照组相比,模型对照组小鼠定向游泳实验潜伏期显著延长(P<0.05)不同运动量可以不同程度的改善小鼠微循环、提高耐缺氧能力,提高痴呆小鼠的学习记忆能力。结论不同运动量能不同程度的改善小鼠的学习记忆障碍,其作用机制可能与不同运动量可以不同程度的改善微循环、提高耐缺氧能力有关。Objective To investigate the effect of exercise volume on senial dementia in mice deficits and determine the mechanism preliminarily.Method After 4 weeks of exercise with the running wheels,water maze task was used to evaluate the learning and memory function of mice,The BI-2000 image system was used to evaluate the microcirculation in mice＇s ala auris,The survival time and persistent time of gasping were observed on acute anoxia mice.Result As compared with control group,the escape latency in directional swimming was prolonged and exercise prolonged the escape latency and improved the microcirculation and enhanced the effect of anti-anoxia in mice.Conclusion These results suggest that exercise has improving effect on learning and memory in mice deficits.The mechanism may be related to improving the microcirculation and enhancing the effect of anti-anoxia,And has relationship with exercise volumn.

关 键 词：老年痴呆 防治 机制 

分 类 号：R749.16[医药卫生—神经病学与精神病学]