壳聚糖/四角蛤蜊多糖载药微球的制备与表征  

Preparation and Characterization of Chitosan/MVPS Microspheres

作　　者：吴秋惠[1] 王令充[1,2] 吴皓[1,2] 王文渊[1] 嵇晶[1] 陈士勇[1] 

机构地区：[1]南京中医药大学药学院,南京210046 [2]南京中医药大学海洋药物研究室,南京210046

出　　处：《中国药师》2011年第10期1403-1406,共4页China Pharmacist

基　　金：国家自然科学基金项目(编号:30900293);国家海洋局公益性行业科研专项基金项目(编号:200705009);江苏省中医药局科技项目(编号:LZ09023)

摘　　要：目的:以壳聚糖、四角蛤蜊多糖(MVPS)作为复合载体材料,以盐酸二甲双胍为模型药物,采用喷雾干燥的方法制备盐酸二甲双胍复合微球。方法:采用正交试验得出了载药复合微球的最佳工艺条件。利用扫描电镜,粒度分析仪以及X射线扫描仪对微球的微观结构和粒度以及物相进行了表征。结果:最佳工艺奈件为:入口温度110℃,空气流量667 m^3·h^(-1),材药比3:1,进料速度2.7ml·min^(-1)。结论:通过紫外分光光度法测定最佳工艺条件下的收率、载药量、包封率分别为(75.07±2.48)%、(22.31±0.38)%、(89.22±1.53)%,复合载药微球表面较为光滑,平均粒径为4.84μm,粒度分布范围较窄,呈正态分布;形成微球后药物以分子形式存在。Objective： To prepare mefformin hydrochloride microspheres by spray drying method with mactra veneriformis polysaccharide （MVPS） and chitosan as the raw materials. Method： The optimum preparation conditions of mefformin hydroehloride microspheres were decided by the orthogonal experiment. The microcosmic structure, phases and size of the microspheres were analyzed by scanning electron microscope analysis and X-ray diffraction. Result： The optimal process was as the follows：inlet temperature of 110 ℃, air flow rate of 667 m^3 · h ^- 1, drug and material ratio of 3 ： 1 , feed rate of 2. 7 ml· min^ - 1. Conclusion ： Determined by UV spectrophotometry, the product yield, drug loading and encapsulation efficiency of the microspheres under the optimal conditions was （75.07 ± 2. 48）%, （22. 31 ±0. 38）% and（89. 22 ± 1.53）% ,respectively. The surface of the microspheres is smooth,and the average particle size was 4. 84 μm with narrow and normal distribution. The drug shows molecular form in the microspheres.

关 键 词：壳聚糖 四角蛤蜊多糖 微球 喷雾干燥 

分 类 号：R944.9[医药卫生—药剂学]