阿尔采末病APP分泌酶及其靶向干预研究进展  

Progress of APP secretase and targeted intervention on Alzheimer's disease

作　　者：李守业[1] 朱妍[1] 焦悦[1] 李昌煜[1] 

机构地区：[1]浙江中医药大学,浙江杭州310053

出　　处：《中国药理学通报》2011年第10期1349-1353,共5页Chinese Pharmacological Bulletin

基　　金：浙江省科技计划资助项目(No2007C23021);浙江省研究生创新科研资助项目(No71015111);浙江省新苗人才计划资助项目(No2010R410016)

摘　　要：α、β和γ3种分泌酶是淀粉样前体蛋白(APP)加工及代谢的关键酶,选择性地激活α分泌酶或抑制β和γ分泌酶,将有助于减少β-淀粉样蛋白(Aβ)的产生,并可能成为治疗AD的有效靶点。该文主要对APP 3种分泌酶活性表达的影响因素及其靶向干预研究的进展做一综述。α,β and γ secretases are three kinds of key enzymes in processing and metabolizing amyloid precursor protein（APP）.Their selective activation of the α secretase or inhibition of β and γ secretase will help reduce the production of β-amyloid protein（Aβ）,and may become one of the effective targets to treating AD.This paper aims to make a review on the research development of relevant factors influencing the activity and expression of 3 APP secretases and their targeted intervention in pharmaceutical studies.

关 键 词：阿尔采末病 Β-淀粉样前体蛋白 分泌酶 靶向干预 激动剂 抑制剂 机制 

分 类 号：R-05[医药卫生] R341