皮下植入无机三氧化聚合物复合磷酸氢二钠的组织学反应  

Histological Reaction to the Subcutaneous Implantation of Mineral Trioxide Aggregate Mixed with Disodium Hydrogen Phosphate

作　　者：杨清岭[1] 徐琛媛[1] 董波[2] 赵玥[1] 孔宇[1] 赵晶晶[3] 

机构地区：[1]佳木斯大学附属口腔医院儿童牙病科,黑龙江佳木斯154002 [2]佳木斯大学附属口腔医院牙体牙髓病1科 [3]上海市第十人民医院口腔科

出　　处：《口腔医学研究》2011年第9期772-774,共3页Journal of Oral Science Research

摘　　要：目的:评价大鼠皮下植入无机三氧化聚合物复合15%磷酸氢二钠(Na2HPO4)水溶液后的炎症反应。方法:将2个填有MTA、MTA复合15%Na2HPO4的硅胶管和1个空硅胶管(空白对照)植入SD大鼠背部皮下组织内,分别于植入后的第1、4和12周处死动物,取出植入体,组织切片观察,并进行炎症分级。结果:1周MTA组与MTA+Na组及对照组炎症分级情况有明显差异(P<0.05),MTA+Na组与对照组无明显差异,4、12周组间无明显差异。结论:MTA复合15%Na2HPO4水溶液后具有更好的组织相容性。Objective： To evaluate the inflammatory reaction subsequent to subcutaneous implantation of mineral trioxide aggregate（MTA） mixed with 15% disodium hydrogen phosphate（Na2HPO4） in rats.Methods： Silicone tubes filled with MTA mixed with 15% Na2HPO4 and MTA alone and empty tubes serving as control group were implanted into subcutaneous tissue on the backs of SD rats and sacrificed after 1,4 and 12 weeks.Histological sections were observed under a light microscope and categorized the inflammatory reactions.Result： After 1 week,MTA alone,was significantly differed from MTA＋Na group and control group（P0.05） while MTA＋Na group had no significant difference from control group.There was no significant difference at 4 and 12 weeks between three groups.Conclusion： MTA mixed with Na2HPO4 was more biocompatible than MTA alone.

关 键 词：炎症反应 无机三氧化聚合物 磷酸氢二钠 

分 类 号：R783.1[医药卫生—口腔医学]