局部晚期非小细胞肺癌适形调强放疗联合多西他赛同步化疗的临床观察  

Intensity modulated radiation therapy combined with docetaxl chemotherapy for locally late stage non-small cell lung cancer

作　　者：邢晓波[1] 张美莲[2] 王宗站[1] 周宓[1] 杨金霞[1] 

机构地区：[1]青岛市肿瘤医院放疗科,山东青岛266042 [2]青岛市肿瘤医院检验科,山东青岛266042

出　　处：《中华肿瘤防治杂志》2011年第16期1280-1282,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨适形调强放疗联合多西他赛对局部晚期非小细胞肺癌(NSCLC)的疗效及不良反应。方法:将65例NSCLC患者,随机分为A组(35例)和B组(30例)。A组35例,采用适形调强放疗联合多西他赛和顺铂同步化疗,放疗后再予以多西他赛及顺铂化疗2个周期;B组30例,采用适形调强放疗结束后,予以多西他赛和顺铂化疗4～6个周期。结果:A组和B组有效率(RR)分别为82.9%和60.0%,两组比较差异有统计学意义,P=0.04;A组1和2年生存率分别为77.1%和48.6%,B组1和2年生存率分别为73.3%和43.3%,两组差异无统计学意义,P=0.63;A组和B组白细胞降低发生率分别为77.1%和53.3%(P=0.123),放射性食管炎分别为65.7%和53.3%(P=0.582),放射性肺炎分别为45.7%和40.0%,P=0.898。结论:适形调强放疗联合多西他赛同步化疗在近期疗效上优于序贯化疗,在不良反应上无差别。OBJECTIVE： To evaluate the effect of intensity modulated radiation therapy（IMRT） combined with Docetaxl chemotherapy for locally late stage non-small cell lung cancer.METHODS：Totally 65 NSCLC patients were involved.Group A consisted of 35 patients,treated with IMRT combined Docetaxel and Cisplatin chemotherapy,and after radiation therapy,they received Docetaxel and Cisplatin chemotherapy for two therapy cycles.Group B consisted of 30 patients,receiving IMRT,then Docetaxel and Cisplatin chemotherapy for 4-6 therapy cycle.RESULTS： The overall response rate（CR＋PR）was 82.9% in Group A,and 60.0% in Group B.The overall response rate of Group A was higher than Group A（P=0.04）;The one-year and two-year survival rate of Group A were 77.1% and 48.6%,and that of Group B were 73.3% and 43.3% respectively.There were no significant differences between Group A and Group B in one-year and two-year survival rate（P=0.63）.The incidence of leucopenia was 77.1% in Group A,and 53.3% in Group B（P=0.123）;The incidence of radiation-induced esophagitis was 65.7% in Group A,and 53.3% in Group B（P=0.582）.The incidence of radiation-induced pulmonitis was 45.7% in Group A,and 40.0% in Group B（P=0.898）.CONCLUSION： The short-term effect of intensity modulated radiation therapy（IMRT） combined with Docetaxl is better than sequential radiotherapy and chemotherapy,while there are no significant differences in adverse reactions between the two treatment.

关 键 词：癌 非小细胞肺 适形调强放疗 同步放化疗 序贯放化疗 

分 类 号：R734.2[医药卫生—肿瘤]