基于体素模型的中子外照射小鼠器官剂量分布  

Organ Dose Distribution for External Neutron Irradiation Based on a Voxel Mouse Model

作　　者：张晓敏[1] 谢向东[1] 曲德成[1] 宁静[1] 袁勇[1] 潘洁[1] 杨国山[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《中国科学：生命科学》2011年第10期919-924,共6页Scientia Sinica(Vitae)

摘　　要：获得外照射条件下动物的器官剂量,为生物效应评价、剂量-效应关系研究提供准确的剂量信息和依据,是近年来辐射生物效应研究的热点.本文基于建立的一个质量为26.9g的小鼠体素模型(体素精度为0.2mm×0.2mm×0.2mm,体素数量为9424000),利用蒙特卡罗方法计算了5种照射几何条件(左侧向、右侧向、腹背向、背腹向和各向同性)下,中子能量为10-9～20MeV共37个能量点的小鼠器官剂量转换系数,基于此套数据,在照射条件已知情况下,可以获得小鼠的器官剂量;分析讨论了照射几何条件、中子能量及器官的位置对小鼠器官剂量的影响.To provide more accurate information and basis for evaluating biological effects and dose-effect relation research by obtaining the organ dose of the animal under external irradiation conditions is a research hotspot of radiation biological effect in recent years.In this paper,a voxel mouse model comprising a total number of 9424000 voxels with a size of 0.2 mm×0.2 mm×0.2 mm was constructed.Monte Carlo simulation was carried out to obtain organ dose conversion coefficients for 37 external monoenergetic neutron beams between 10？9 and 20 MeV under five different irradiation geometry conditions（left lateral,right lateral,dorsal-ventral,ventral-dorsal,anisotropic）.Organ dose conversion coefficients were presented in this paper to get the organ dose of the mouse when the irradiation condition was known.The effect of irradiation geometry conditions,neutron energy and the location of organs on the organ dose of mice was discussed and analyzed in the end.

关 键 词：器官剂量 中子外照射 小鼠 体素模型 

分 类 号：R-332[医药卫生] R811