首发抑郁症患者脑兴趣区的磁共振质子波谱分析  

The analysis of magnetic resonance spectroscopy in the region of interest of the first episode depression

作　　者：王冬青[1] 朱彦[1] 罗一烽[1] 李月峰[1] 李国海[2] 刘珺[2] 朱颖[1] 殷瑞根[1] 吴琴[3] 赵亮[1] 

机构地区：[1]江苏大学附属医院影像科,江苏镇江212000 [2]江苏大学附属第四人民医院精神科 [3]江苏大学电气学院

出　　处：《实用放射学杂志》2011年第9期1299-1301,1332,共4页Journal of Practical Radiology

基　　金：江苏省卫生厅科技计划资助项目（H200951）;镇江市科技计划项目（SH2009017）.

摘　　要：目的 探讨首发抑郁症患者额叶白质、海马及杏仁核的脑代谢有无异常.方法 利用质子磁共振波谱分析（1HMRS）技术检测20例首发抑郁症患者和20名健康志愿者的额叶白质、海马及杏仁核的多个代谢指标,包括N-乙酰天门冬氨酸盐（NAA）、胆碱复合物（Cho）、肌醇（MI）、肌酸（Cr）.结果 与对照组相比,抑郁症组患者双侧额叶白质的Cho/Cr值上升（左：t=2.62,P=0.04;右：t=2.68,P=0.05）,MI/Cr值下降（左：t=2.9,P=0.03;右：t=3.1,P=0.02）;抑郁症组患者双侧海马的NAA/Cr、Cho/Cr均低于对照组（NAA/Cr：左t=3.06,P=0.004;右t=3.54,P=0.001.Cho/Cr：左t=2.94,P=0.006;右t=4.02,P=0.001）;抑郁症组患者双侧杏仁核的Cho/Cr、NAA/Cr比值均明显低于对照组（Cho/Cr：左t=5.035,P=0.007;右t=8.681,P=0.001,NAA/Cr：左t=9.899,P=0.001;右t=7.227,P=0.002）.结论 额叶白质、海马及杏仁核的代谢异常可能构成首发抑郁症的神经生物学基础.Objective To explore the abnormality of the brain＇s metabolism in the white matter of frontal lobe ,hippocampus and amygdala of first episode depressive first episode depression patients. Methods The metabolic indexes of the white matter of frontal lobe,hippocampus and amygdala in 20 patients with first episode depression and 20 healthy volunteer were analysed using proton magnetic resonance spectroscopy（MRS） ,including NAA,Cho,MI,Cr. Results The values of Cho/Cr of the white matter of frontal lobe of the depressive patients group increased （ left t= 2.62, P = 0.04, right t = 2.68, P = 0.05 ）, the values of MI/Cr of the white matter of frontal lobe decreased（left t= 2.9, P= 0.03, right t= 3.1, P=0.02） ;the values of NAA/Cr and Cho/Cr of the bilateral hippocampus of the depressive patients group were both lower （NAA/Cr：left t= 3.06, P= 0. 004, right t= 3.54, P = 0. 001. Cho/ Cr：left t=2.94, P=0. 006, right t=4.02, P=0. 001） ;The values of NAA/Cr and Cho/Cr of the amygdala of the depressive patients group were significantly higher （NAA/Cr：left t=9. 899, P=0. 001,right t=7. 227, P=0. 002 . Cho/Cr ： left t=5. 035, P= 0. 007, right t=8. 681, P=0. 001） ,as compared with that of control group, respectively. Conclusion The metabolic abnormalities of white matter of frontal lobe ,hippocampus and amygdala maybe constitute the nervous biochemical basis of first episode depression.

关 键 词：抑郁症 磁共振波谱 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]