子宫颈癌高危型人乳头瘤病毒16/18的表达及其临床意义  

Clinical significance of the expression of human papilloma virus in cervical carcinoma

作　　者：靳丽杰[1] 凌斌[2] 

机构地区：[1]蚌埠医学院第一附属医院妇产科,安徽蚌埠233004 [2]安徽医科大学附属省立医院妇产科,安徽合肥230032

出　　处：《蚌埠医学院学报》2011年第10期1064-1066,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨子宫颈癌组织中高危型人乳头瘤病毒(HPV)16/18表达及其与临床病理参数之间的关系。方法:采用免疫组织化学法检测42例子宫颈癌和30例正常子宫颈组织中HPV 16/18表达,分析其表达与患者临床病理参数的关系。结果:与正常子宫颈组织相比,子宫颈癌中HPV 16/18阳性率明显增加(P<0.01)。子宫颈癌淋巴结中HPV 16/18阳性率与子宫颈癌临床分期和淋巴结转移有一定关系(P=0.032),而与肿瘤细胞分化度和患者的发病年龄均无明显关系(P>0.05和P=1.000)。结论:子宫颈癌组织中HPV 16/18检出率与子宫颈癌临床病理参数之间存在一定关系,子宫颈癌组织中HPV 16/18检测可作为预测子宫颈癌淋巴转移的一项参考指标。Objective：To investigate the relationship between the expression of human papilloma virus（HPV） 16/18 and the clinicopathologic parameters in cervical carcinoma.Methods：S-P immuno-histochemical method was used to detect the expression of HPV 16/18 in 42 patients with cervical carcinomas and 30 normal cervical tissues.The association between the expression of HPV 16/18 and the clinicopathologic parameters（such as age,histologic grade,clinical stage and lymph node metastasis） in cervical carcinomas was assessed.Results： The expression of HPV 16/18 in cervical carcinoma was significant higher than that in normal cervical tissues（P0.01）.The expression of HPV 16/18 in lymph node was correlated with the clinical stage and lymph node metastasis of cervical carcinoma（P=0.032）,but not related to the tumor histological grade or patients′ age（P0.05 and P=1.000）.Conclusions：The expression of HPV 16/18 is correlated with the clinicopathologic parameters and prognosis of cervical carcinoma,and may serve as a useful reference index to judge the lymph node metastasis of the cervical carcinoma.

关 键 词：子宫颈肿瘤 人乳头瘤病毒 表达 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]