抑癌基因XEDAR的研究进展  

Research Progress in Tumor-suppressor Gene XEDAR

作　　者：杨丽虹[1] 黄晓俊[1] 金安琴[1] 陈平[1] 

机构地区：[1]兰州大学第二医院消化科,甘肃兰州730000

出　　处：《现代生物医学进展》2011年第20期3988-3990,共3页Progress in Modern Biomedicine

摘　　要：X-连锁性外胚层发育不良受体(X-linked ectodermal dysplasia receptor,XEDAR)基因位于人类染色体Xq12,编码的蛋白XEDAR作为新近分离出来的肿瘤坏死因子受体家族成员其功能主要涉及细胞增殖、参与细胞分化(胚胎的发育,表皮的分化)、调亡等。XEDAR已在多种肿瘤组织中研究,笔者就其基本概念及在肿瘤研究方面的进展进行综述。X - linked ectodermal dysplasia receptor（XEDAR）, as a recently isolated member of the tumor necrosis factor receptor family, is encoded by the X - linked ectodermal dysplasia receptor （XEDAR） gene which on the X chromosome .The function of XEDAR mainly involves cell proliferation, differentiation （embryonic development and differentiation of epidermis）, apoptosis, etc. XEDAR has been studied in a wide variety of tumor tissue, this review is mainly based on its concept and research progress in cancer.

关 键 词：XEDAR基因 抑癌基因 凋亡 肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]