儿童过敏性紫癜急性期FOXP3表达及其意义分析  

The FOXP3 gene expression in children with Hench-Schnlein purpura during acute phase and analysis of its significance

作　　者：马继军[1] 宋力[2] 胡坚[1] 

机构地区：[1]天津市儿童医院免疫科,天津300074 [2]天津市儿童医院儿科研究所,天津300074

出　　处：《中国实用儿科杂志》2011年第10期763-766,共4页Chinese Journal of Practical Pediatrics

摘　　要：目的探讨过敏性紫癜(HSP)患儿急性期外周血白细胞转录因子FOXP3基因表达情况及其与发病机制间的关系。方法 2008年11月至2009年4月在天津市儿童医院风湿免疫科住院的HSP患儿(HSP组)50例、KD患儿(KD组)34例及门诊择期行扁桃体切除术体检无异常儿童(对照组)50例,检测其外周血白细胞FOXP3 mRNA表达(剔除非特异性扩增标本)。结果 3组共计44例最终进入统计学分析,其中HSP组17例,KD组14例,对照组13例。HSP组急性期外周血白细胞FOXP3 mRNA的表达与对照组比较显著降低,差异有统计学意义(P<0.05);KD组外周血FOXP3 mRNA表达也较对照组减低,差异有统计学意义(P<0.05)。但HSP组与KD组间比较,差异无统计学意义(P>0.05)。结论 FOXP3表达减低可能为导致儿童期系统性血管炎免疫失衡的共同原因,但并非HSP的特异性改变。Objective This study aimed to explore the relationship between the gene expression of FOXP3 and the pathogenesis of Henoch-Schonlein pnrpura in children during the acute phase. Methods The mRNA expression of FOXP3 in the peripheral blood determined in 50 HSP children （HSP group）, 34 KD children （KD group and 50 children who would receive tonsillectomy with normal physical examination （corltrol group） respectively. Results Altogether 44 cases were included in the final statistical anaylsis, 17 in HSP group, 14 in KD group and 13 in control group. The mRNA expression of FOXP3 in patients with HSP was remarkably decreased compared to the healthy controls, and there was significant difference between the two groups （P 〈 0.05）. The mRNA expression of FOXP3 in patients with KD was also decreased compared to the healthy controls, the difference showing statistical significance （P 〈 0.05）.But no statistical difference Was found in the mRNA expression of FOXP3 in patients with HSP and KD （P 〉 0.05）. Conclusion The decrease of FOXP3 expression might be the indication of immune imsbalance of systematic vasculitis in children, not the specific manifestation of HSP.

关 键 词：紫癜 过敏性 MRNA FOXP3 基因表达 儿童 

分 类 号：R72[医药卫生—儿科]