OPN及VEGF在膀胱尿路上皮癌中的表达及意义  

Significance about expression of OPN and VEGF in human bladder urothelial carcinoma

作　　者：徐松涛[1] 邵雪峰[1] 王竟[2] 范波[2] 

机构地区：[1]江苏太仓市第一人民医院泌尿外科,江苏太仓215400 [2]江苏常熟市第一人民医院,江苏常熟215500

出　　处：《中国现代医学杂志》2011年第26期3276-3278,3283,共4页China Journal of Modern Medicine

摘　　要：目的研究骨桥蛋白(OPN)及血管内皮生长因子(VEGF)在膀胱尿路上皮癌(简称膀胱癌)组织中的表达,探讨其相互关系及临床病理意义。方法采用免疫组织化学方法检测OPN及VEGF蛋白在61例膀胱癌和11例膀胱正常黏膜中的表达。结果膀胱癌组织中OPN蛋白阳性率为59.0%,显著高于膀胱正常黏膜组织(18.2%)(P<0.05)。VEGF在膀胱癌组织中蛋白阳性率为65.6%,显著高于膀胱正常黏膜组织(9.1%)(P<0.05)。结论 OPN蛋白表达增高与膀胱癌的临床分期及复发密切相关,并与VEGF相关。联合检测OPN和VEGF有助于膀胱癌的侵袭转移能力的评估,并可判断膀胱癌生物学行为。【Objective】 To investigate the expression of OPN and VEGF in human bladder urothelial carcinoma（BUC）.【Methods】 61 cases of in BUC were evaluated for OPN and VEGF protein expression by immunohistochemical method.【Results】 The positive expression level of OPN was 59.0% in human BUC which was higher than that in normal bladder mucosa（18.2%）（P〈0.05）.The positive expression level of VEGF is 65.6% in BUC which was higher than that in normal bladder mucosa（9.1%）（P〈0.05）.【Conclusion】 Increased expression of OPN is markedly correlated with cell clinical classification of BUC,and correlated with the expression of VEGF.Detection of OPN and VEGF may be helpful to evaluate prognosis and infiltrative capability of BUC.

关 键 词：膀胱癌 骨桥蛋白 免疫组织化学 血管内皮生长因子 

分 类 号：R737.14[医药卫生—肿瘤]