睡眠剥夺应激对大鼠心电图的影响  

The Effect of Sleep Deprivation on ECG in Rats

作　　者：王新兴[1] 赵云[1] 万帝[2] 梅竹松[1] 刘伟丽[1] 战锐[1] 冷雪[1] 弓景波[1] 钱令嘉[1] 

机构地区：[1]中国人民解放军军事医学科学院卫生学环境医学研究所,天津300050 [2]华北煤炭医学院公共卫生系

出　　处：《中国慢性病预防与控制》2011年第5期483-485,共3页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家自然科学基金项目(81000584;30770843)

摘　　要：目的观察睡眠剥夺应激大鼠心电图的变化规律。方法以改良水环境多平台睡眠剥夺法(MMPM)建立睡眠剥夺模型,设大平台对照组,睡眠剥夺1、3、5、7d组,每组9只雄性Wistar大鼠。分别记录各组心电图,分析大鼠心率和心电图变化情况。结果与对照组比较,睡眠剥夺1d后大鼠心率明显下降,差异有统计学意义(P<0.05);睡眠剥夺3d后心电图PR间期、T波波幅均明显高于对照组,并随睡眠剥夺时间的延长而增加,差异有统计学意义(P<0.05);而睡眠剥夺3d后大鼠心电图QRS间期较对照组明显缩短,差异有统计学意义(P<0.05);睡眠剥夺3d后大鼠体重明显下降,差异有统计学意义(P<0.05)。结论睡眠剥夺导致以心动过缓为主要表现的心电图变化,并可导致心肌缺血样心电图改变。Objective To observe the effect of sleep deprivation on ECG in rats. Methods The insomnia rats were produced by modified multiple platform suspended in water method, while a large platform group was set as control. Open-field test was applied to evaluate behavior of the model rats. The 45 rats were distributed into control group and sleep deprivation groups （sleep deprivation for 1, 3, 5, 7 d, respectively） randomly. Results The heart rates of the sleep deprivation rats showed a significant reduction from the first to the seventh day compared with the control group （P〈0.05）. The PR interval and T wave interval were extended significantly from the third to the seventh day in sleep deprivation rats compared with the control group （P〈0.03）. The QRS interval was abbreviated significantly from the third to the seventh day in sleep deprivation rats compared with the control groups （P〈0.05）. The sleep deprivation rats showed decreased body weight and reduced significantly in the third ,fifth, seventh day compared with the control group （P〈0.05）. Conclusion Sleep deprivation can induce bradycardia and myocardial ischemia changes of ECG in rats and suppress the increase of body weight in rats.

关 键 词：睡眠剥夺 心电图 应激大鼠 

分 类 号：R730.54[医药卫生—肿瘤]