碱性离子液体[bmim]OH促进一锅串联合成七元硫杂环化合物  

A Facile and Efficient One-Pot Synthesis of Seven-Membered Sulfur Heterocyclic Compounds Using OH as Catalyst and Solvent

作　　者：娄凤文[1] 周建峰[1] 林贤福[2] 陈志春[2] 

机构地区：[1]淮阴师范学院化学化工学院江苏省低维材料化学重点建设实验室,淮安223300 [2]浙江大学化学系,杭州310027

出　　处：《有机化学》2011年第10期1607-1612,共6页Chinese Journal of Organic Chemistry

基　　金：江苏省低维材料化学重点建设实验室开放基金(Nos.JSKC09062;JSKC10086)资助项目

摘　　要：碱性离子液体[bmim]OH能快速、高选择性地催化有机硫试剂与丙烯酸乙烯酯之间的直链加成反应.通过这种方法,合成了12种β-烷基硫取代的丙酸乙烯酯类含硫化合物.进一步调控反应温度和时间可以实现Michael加成和分子内的加成-消除反应的一锅串联成环反应.利用碱性离子液体[bmim]OH选择性促进巯基亲核性的策略,成功地合成了6种七元硫杂环化合物,对产物进行了表征确定.A rapid method for the straight chain addition of thiols to vinyl acrylates was developed by using basic ionic liquid OH as catalyst and solvent.The basic ionic liquid used as catalyst for the cascade reaction of Michael addition and intramolecular addition-elimination reaction in one pot was applied to syn-thesize a series of sulfur heterocycles bearing lactone or lactam functional groups.In this paper,18 com-pounds were synthesized including 12 Michael adducts and 6 sulfur heterocycles.These compounds were characterized by 1H NMR and 13C NMR spectra.

关 键 词：[bmim]OH 硫醇 丙烯酸乙烯酯 杂环化合物 选择性 

分 类 号：O626[理学—有机化学]