由α-氰基二硫缩烯酮制备多取代喹唑啉酮化合物  

Synthesis of Polysubstituted Quinazolinones from the Continuous Reaction of α-Cyano Disulfide Ketene

作　　者：刘璇[1] 史大昕[1] 唐健红[1,2] 张奇[1] 李加荣[1] 

机构地区：[1]北京理工大学化工与环境学院,北京100081 [2]华侨大学化工学院,厦门362021

出　　处：《有机化学》2011年第10期1710-1713,共4页Chinese Journal of Organic Chemistry

摘　　要：以α-氰基乙酸甲酯为起始原料,经与二硫化碳、碘甲烷反应先得到α-氰基二硫缩烯酮1,1与苯乙酮2反应得2H-吡喃-2-酮-3-腈化物3,碱诱导下3再与丙二腈经环转化得到多取代邻氨基芳香腈4,4与酮5在氢氧化钠催化下环化得到多取代喹唑啉酮目标物6.这组连续转化合成多取代喹唑啉酮的反应具有原料简便、反应温和等优点.α-Cyano disulfide ketene 1,obtained from the reaction of α-methyl cyano-acetate,carbon disul-fide and methyl iodide,condensated with acetophenone 2 to provide 3-cyano-2H-pyran-2-ketones 3,then ring transformation of 3 and malononitrile under base afforded aromatic o-amino dinitriles 4,and 4 reacted with ketone 5 to give the polysubstituted quinazolinone 6.This continuous reaction for the convenient syn-thesis of polysubstituted quinazolinone 6 has the follow advantages： simple raw materials,mild reaction condition,and simple operation.

关 键 词：α-氰基二硫缩烯酮 2H-吡喃-2-酮-3-腈化物 邻氨基芳香二腈 喹唑啉酮 连续反应 

分 类 号：TQ252[化学工程—有机化工]