丙烯海松双酰基硫脲衍生物的合成及抑菌活性研究  

Synthesis and Antibacterial Activity of Diacylthiourea Derivatives Containing Acrylpimaryl Group

作　　者：李健[1] 饶小平[1,2] 商士斌[1,2,3] 高艳清[1] 

机构地区：[1]中国林业科学研究院林产化学工业研究所生物质化学利用国家工程实验室国家林业局林产化学工程重点开放性实验室江苏省生物质能源与材料重点实验室,江苏南京210042 [2]中国林业科学研究院林业新技术研究所,北京100091 [3]江苏强林生物能源有限公司,江苏溧阳213364

出　　处：《林产化学与工业》2011年第5期1-5,共5页Chemistry and Industry of Forest Products

基　　金：林业公益性行业专项(200704008)

摘　　要：松香与丙烯酸通过Diels-Alder双烯加成反应得到丙烯海松酸,丙烯海松酸经酰氯化和硫脲化合成了6个未见报道的双酰基硫脲衍生物,通过IR、NMR、MS和元素分析等对产物进行了表征。初步的活性结果显示,丙烯海松双酰基硫脲衍生物对大肠杆菌和金黄色葡萄球菌都具有较好的抑制作用,特别是丙烯海松双-(3,5-二苯基)硫脲(4f)对大肠杆菌的抑菌活性比市售杀菌剂新洁尔灭高。Acrylpimaric acid was prepared from rosin through Diels-Alder addition reaction,then series of diacylthiourea derivatives containing acrylpimaryl group were synthesized.Their structures were characterized by IR,NMR,MS,and elemental analysis.The antibacterial activity of diacylthiourea derivatives against Gram-negative bacteria and Gram-positive bacteria were also investigated.The results indicated that diacylthiourea derivatives displayed extensive anti-bacterial activity against Gram-negative bacteria and Gram-positive bacteria.Especially,compared with commercial anti-bacterial agent（bromogeramine）,compound 4f exhibits superior anti-bacterial activity against Escherichia coli（Gram-negative bacteria）.

关 键 词：松香 丙烯海松酸 双酰基硫脲 抑菌活性 

分 类 号：TQ351[化学工程]