首发精神分裂症患者血浆非酶抗氧化物浓度与临床特征  

Plasma non-enzyme antioxidants levels and clinical features in first-episode patients with schizophrenia

作　　者：李艳丽[1] 杨甫德[1] 谭云龙[1] 朱凤艳[1] 王宁[1] 陈松[1] 王志仁[1] 周东丰[2] 

机构地区：[1]北京回龙观医院精神医学研究中心,北京100096 [2]北京大学精神卫生研究所卫生部精神卫生重点实验室(北京大学),北京100191

出　　处：《中国心理卫生杂志》2011年第10期756-759,共4页Chinese Mental Health Journal

基　　金：北京市优秀人才培养基金(20061D0301400098);国家自然科学基金(30770782);北京市自然科学基金(7092047)

摘　　要：目的:探讨在首发精神分裂症患者中血浆非酶抗氧化物浓度与临床特征的关系。方法:选择符合国际疾病分类第十版(ICD-10)的精神分裂症诊断标准首发患者64例,作为病例组(包括家族史阳性30例,阴性34例)和42名健康成人作为对照组,分别测定血浆白蛋白、总胆红素和尿酸浓度。病例组采用阳性和阴性症状量表(PANSS)评定精神病理症状。结果:病例组血浆白蛋白和尿酸浓度低于对照组(P均<0.05);家族史阳性患者白蛋白和胆红素浓度低于家族史阴性患者(P均<0.05);家族史阳性患者病程与尿酸浓度呈负相关(r=-0.50,P<0.05),阴性症状分与白蛋白和尿酸浓度呈负相关(r=-0.37,-0.41,P<0.05)。结论:精神分裂症首发患者血浆非酶抗氧化能力下降,而且可能与阴性症状、家族史有关。Objective： To investigate the relationships between the plasma non-enzyme antioxidants levels and clinical features in first-episode patients with schizophrenia, Methods： Sixty-four first-episode patients with schizophrenia who met the criteria of schizophrenia of the International Statistical Classification of Diseases and Related Health Problems 10th Revision （ICD-10） and 42 healthy volunteers were included in this study. The patient group was divided into sub-group with family history （ n = 30） and without family history （ n = 34）. The subjects were assessed with the Positive And Negative Symptom Scale（PANSS） and their albumin, bilirubin and uric acid levels in plasma were examined. Results： The plasma albumin [（44. 5±3.3） g/L vs, （46.7 ±3.4） g/L] and uric acid [（3.2 ±0. 9） x 102μmol/L vs. （5.0±1.0） ×102μmol/L] were significantly lower in patients than in controis （Ps 〈 0. 05）. The patients with family history had lower plasma albumin [ （43.4 ± 3.1） g/L vs. （45.5 ± 3.2） g/L] and bilirubin [（ 11.4 ± 3.7） p^mol/L vs. （ 13.1 ± 3.8） μmol/L] than those without family history （Ps 〈 0. 05）. In patients with family history, the illness duration was negatively correlated with the uric acid levels （r = - 0. 50, P = 0. 004） and the negative subscore of PANSS was negatively correlated with albumin concentrations （ r =-0.41, P = 0. 017）. Conclusion： The levels of non - enzyme antioxidants are decreased in first - episode patients with schizophrenia, which may be related to the negative symptoms and family history of patients with schizophrenia.

关 键 词：精神分裂症 家族史 非酶抗氧化物 未服药 横断面研究 

分 类 号：R749.305[医药卫生—神经病学与精神病学]