乙型肝炎感染后相关疾病-肝硬化和原发性肝癌患者铁代谢的临床观察  

Serum Iron Metabolism in Patients with Hepatitis B Virus Induced Liver Cirrhosis and Hepatocellular Carcinoma

作　　者：李永伟[1] 杨宏志[1] 王拥泽[1] 肖阁敏[1] 滕立春[1] 

机构地区：[1]中山大学附属第三医院中医科,广东广州510630

出　　处：《中国医药指南》2011年第28期202-203,共2页Guide of China Medicine

基　　金：广东省中医药局课题(课题编号:2010102)

摘　　要：目的探讨乙型肝炎后肝硬化(LC)和原发性肝癌(HCC)患者血清中铁(Fe)、血清不饱和铁结合力(UIBC)、总铁结合力(TIBC)和转铁蛋白饱和度(TS)的变化。方法用Ferene法和红菲绕啉直接法检测62例LC和HCC患者血清中Fe、UIBC、TIBC水平,并计算TS。结果 LC患者的Fe和TS较HCC患者明显升高(P<0.05),肝癌组UIBC明显升高(P<0.05),但两组间TIBC无显著差异。结论肝硬化患者存在铁超载,肝癌患者较之肝硬化患者血铁含量明显减少,应对肝硬化阶段的铁超载给予干预。Objective To observe serum Fe, TIBC,UIBC levels and TS percentages in patients with hepatitis B virus induced liver cirrhosis and hepatocellular carcinoma.Methods Ferene or bathophenanthroline tests were used to exmaine serum Fe3＋, TIBC,UIBC levels in 62 patients with LC and HCC,and TS percentages were calculated. Results The serum levels of Fe and TS in patients with LC were significantly higher than that in HCC,serum UIBC levels were higher in HCC than in LC patients,while the serum TIBC levels had no difference between HCC and LC patients. Conclusions Iron overload exists in LC,while iron deficiency in HCC.Iron depletion therapy should administered in LC patients.

关 键 词：铁代谢 乙型肝炎后肝硬化 原发性肝癌 危险因素 

分 类 号：R735.7[医药卫生—肿瘤]