宫颈鳞癌组织中PINCH和血管内皮生长因子C蛋白表达的研究  

Study on the expression of PINCH and vascular endothelial growth factor C in cervical squamous cell carcinoma

作　　者：孟亚丽[1] 郑燕[1] 王立芹[2] 李学慧[1] 朱振龙[3] 张红真[1] 

机构地区：[1]河北医科大学第一医院妇产科,石家庄050031 [2]河北医科大学公共卫生学院流行病与卫生统计学教研室 [3]河北医科大学第一医院病理科,石家庄050031

出　　处：《中国综合临床》2011年第10期1019-1022,共4页Clinical Medicine of China

基　　金：河北省科学技术研究与发展指导计划项目（07275510）

摘　　要：目的探讨宫颈鳞癌组织中PINCH蛋白和血管内皮生长因子C（VEGF-C）蛋白的表达意义。方法应用免疫组化SP法检测58例宫颈鳞癌、30名正常宫颈上皮组织中PINCH蛋白和VEGF-C蛋白的表达，并分析PINCH蛋白和VEGF-C蛋白的表达与临床病理特征的关系。结果58例宫颈鳞癌组织中PINCH和VEGF-C的表达阳性率[分别为（62．1％（36／58）和67．2％（39／58）]高于正常宫颈上皮（0），差异有统计学意义（χ2值分别为31．512、12．534，P均〈0．001）。PINCH蛋白表达与年龄、肿瘤大小、肿瘤组织分化程度无明显相关（P均〉0．05），与有无淋巴结转移及临床分期相关（χ2值分别为9．090、8．263，P均〈0．01）。VEGF-C的表达与患者年龄、肿瘤大小无相关性（P均〉0．05），与有无淋巴结转移、肿瘤组织分级和临床分期相关（χ2值分别为10．775、13．496、5．001，P均〈0．05）。PINCH蛋白及VECF．C蛋白表达有关联（C=0．341，P〈0．01）。结论PINCH和VEGF—C可能协同参与了宫颈鳞癌的发生和发展过程，并在宫颈癌的侵袭和转移机制中发挥着重要作用。Objective To study the expression of PINCH and vascular endothelial growth factor C （VEGF-C） in cervical squamous cell carcinoma; Methods We detected the expression of PINCH and VEGF-C by immunohistochemistry SP in 58 cervical squamous cell carcinoma cases and 30 normal cervical epithelial tissue and analyzed their relationship to the clinical pathological features; Results The expression of PINCH and VEGF-C in 58 cervical squamous cell carcinoma（62. 1% ,36/58 ;67.2% ,39/58 ） were higher than that in normal cervical epithelial tissue （ 0, 0/30 ）. The difference was significant （ χ2 = 31. 512,12. 534, P 〈 0. 001 ） ; The expression of PINCH protein was not significantly associated with the age, tumor size and tumor differentiation grade （ P 〉 0. 05 ）, but was associated with the lymph node metastasis and clinical stage （ χ2 = 9. 090,8. 236 ,P 〈 0. 001 ）. The expression of VEGF-C had no significant correlationship with the age and tumor size （ P 〉 0. 05 ） but had a correlationship with the lymph node metastasis, tumor differentiation grade and clinical stage（ χ2 = 10. 775,13. 496,5. 001 ,P 〈 0. 05 ）. The expression of VEGF-C was correlated with the expression of PINCH protein（ C = 0. 341, P 〈 0. 01 ）. Conclusion It is possible that VEGF-C and PINCH take part in the development and progress of cervical squamous cell carcinoma and play an important role in the invasion and metastasis mechanism altogether.

关 键 词：PINCH蛋白 血管内皮生长因子蛋白 宫颈鳞癌 临床病理 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]