结直肠无蒂型锯齿状腺瘤的临床病理特征  

Clinicopathologic Features of Colorectal Sessile Serrated Adenoma

作　　者：田卫华[1] 杨根源[2] 龚飞跃[2] 

机构地区：[1]广东省珠海市人民医院病理科,519000 [2]广东省珠海市人民医院内镜中心,519000

出　　处：《胃肠病学》2011年第9期566-568,共3页Chinese Journal of Gastroenterology

摘　　要：无蒂型锯齿状腺瘤(SSA)属结直肠锯齿状病变之一,具有独特的形态学特点、生物学行为和分子基因学改变,其内镜形态和组织学特征有别于其他结直肠锯齿状病变,且与新近提出的结直肠癌变的锯齿状通路密切相关。近年研究发现SSA是微卫星不稳定性癌的前期病变,可直接发生癌变。但目前国内尚缺乏对这一病变的认识。本文就SSA的定义、形态学特征和病理组织学诊断标准作一综述,旨在提高临床医师对这一病变的认识。Sessile serrated adenoma （SSA） is one of the colorectal serrated lesions with unique morphological features, biological behavior, molecular and genetic changes. The endoscopic appearance and histological feature of SSA are quite different from those of other colorectal serrated lesions, and are closely related to the newly proposed serrated polyp pathway of colorectal carcinogenesis. It has been recognized in recent studies that SSA is the precursor lesion of microsatellite instability of colorectal cancer and can progress to colorectal cancer directly. But so far little is known about this lesion in China. This article reviewed the definition, morphological features and histopathologic diagnostic criteria for SSA, in order to improve physicians＇ awareness of this lesion.

关 键 词：结直肠肿瘤 无蒂型锯齿状腺瘤 微卫星不稳定性 病理学 临床 

分 类 号：R735.3[医药卫生—肿瘤]