复方苯佐卡因凝胶治疗豚鼠口腔溃疡的实验研究  

Effects of Benzocaine compound gel on oral canker sore in guinea pigs

作　　者：韦宝伟[1] 刘布鸣[1] 陈力力[1] 刘元[1] 姚树汉[1] 

机构地区：[1]广西中医药研究院,南宁530022

出　　处：《实用口腔医学杂志》2011年第5期693-695,共3页Journal of Practical Stomatology

摘　　要：目的:对比仿制药复方苯佐卡因凝胶(以下简称凝胶)与其被仿品(美国非处方药品"Orajel Mouth-Aid,OMA)"对实验性口腔溃疡治疗作用。方法:采用醋酸、细菌或真菌诱发豚鼠口腔溃疡模型观察药物抗口腔溃疡作用。结果:局部给药,凝胶和OMA均能显著促进醋酸、细菌或真菌诱发的豚鼠口腔溃疡愈合,均具有剂量依赖性。结论:凝胶和OMA均具有促进口腔溃疡愈合作用,两药作用强度相当。Objective：To compare the effects of benzocaine compound gel（Gel） and its original product ＂Orajel Mouth-Aid＂（OMA） in the treatment of oral canker sore in guinea pigs.Methods：Oral canker sore models were induced by acetic acid,staphylococcus epidermidis and candida albicans respectively in guinea pigs.The canker sore was treated by Gel and OMA at various dosed respectively.The treatment effects were analysed by the canker sore area change before and after treatment.Results：Gel and OMA showed similar effectiveness and dose-dependent effects in the treatment of canker sore in guinea pigs.Conclusion：Benzocain gel and OMA are effective in promoting the healing of oral canker sore.

关 键 词：苯佐卡因 Orajel Mouth-Aid 口腔溃疡 豚鼠 

分 类 号：R781.5[医药卫生—口腔医学]