脑立体定向术治疗难治性精神分裂症的远期疗效  

Follow-up study on refractory schizophrenia with brain stereotaxis therapy

作　　者：蔡溢[1,2] 匡卫平[1] 郭田生[1] 黄红星[1] 邬志美[1] 周彬[1] 朱勇[1] 陈小峰[1] 李波[1] 谌红献[2] 

机构地区：[1]湖南省脑科医院功能神经外科,长沙410007 [2]中南大学湘雅二医院精神卫生研究所,长沙410011

出　　处：《中南大学学报（医学版）》2011年第9期876-880,共5页Journal of Central South University ：Medical Science

基　　金：湖南省脑科医院资助项目(2010)~~

摘　　要：目的:探讨脑立体定向术治疗难治性精神分裂症远期疗效及安全性。方法:采用脑立体定向术治疗难治性精神分裂症87例,术后随访2年以上;采用临床疗效总评定量表、阳性和阴性症状量表及精神症状简明量表对远期疗效进行评定,采用日常能力量表、社会功能缺陷筛选量表、临床疗效总评量表、韦氏成人智力量表及韦氏记忆量表评估手术安全性。结果:依据临床疗效总评定量表评定标准,87例患者中,显效40例,有效24例,稍有效12例,无变化7例,恶化0例,死亡1例,脱落3例。手术前后各量表评分差异均有统计学意义(P<0.01)。无严重并发症和后遗症。结论:脑立体定向术治疗难治性精神分裂症远期疗效稳定,安全性好;但术后应重视药物维持治疗和社会功能的恢复。Objective To determine the long-term effect and security of refractory schizophrenia with brain stereotaxis multi-target therapy technique. Methods A total of 87 patients with refractory schizophrenia were treated with brain stereotaxis multi-target therapy and were followed up over 2 years. The scores of Clinical Global Impression, Brief Psychiatric Rating Scale, Positive and Negative Symptom Scale, Wechsler Adult Intelligence Scale, Wechsler Memory Scale, Actives of Daily Living, and Social Disability Screening Schedule were compared before and after the operation. Results Of the 87 patients, 40 obviously improved, 24 improved, 12 improved little, 7 did not change. None grew worse, 1 died, and 3 shed. There was a significant difference in the scales before and after the operation （P 〈 0.01 ）. No severe complications and sequelae occurred. Conclusion Stereotaxic multi-target therapy is effective and safe for refractory schizophrenia. After the operation, drug therapy should be maintained and recovery of social function is helpful.

关 键 词：脑立体定向 难治性精神分裂症 远期疗效 安全性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]