Helical CT findings and clinicopathologic features in malignant gastrointestinal stromal tumors: the correlation between radiologic appearance and malignant potential  

恶性胃肠道间质瘤CT特点与临床病理分析比较:影像学表现与恶性潜能相关性分析(英文)

作　　者：Zhifeng Xu Aizhen Pan Fang Yong Yingyu Chen Bin Li Qiang Gao Renhua Wu 

机构地区：[1]Department of Medical Imaging, The First People＇s Hospital of Foshan, Foshan 528000, China [2]Department of Medical Imaging, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2011年第11期643-649,共7页中德临床肿瘤学杂志（英文版）

基　　金：Supported by grants from the National Natural Science Foundation of China (Key program, No. 30930027);Natural Science Foundation of Guangdong Province (No. 8151503102000032)

摘　　要：Objective： In this pictorial essay, we described the clinical, pathologic, and computed tomographic （CT） findings of malignant gastrointestinal stromal tumors （MGISTs） and attempt to establish the correlation between radiologic appearance and malignant potential. Methods： This retrospective analysis included 20 patients receiving treatment for MGIST between 2008 and 2010. The diagnosis was established by pathology and immunohistochemistry. All these patients underwent pre- operative CT. Clinical presentation, pathology and CT images were analyzed. Helical CT images were reviewed for morpho- logic features such as tumor size, number and location, tumor margins, necrosis, degree of enhancement and metastasis. Results： Gastrointestinal bleeding, abdominal pain and discomfort, and without clinical symptom were common findings and were observed in 9 （45%）, 6 （30%）, and 5 （25%） of the 20 patients. 8 （40%） tumors were located in stomach, and 10 （50%）, 1 （5%） and 1 （5%） were located in small intestine, mesentery and peritoneum, respectively. Male to female ratio was about 1：2. The size of MGIST ranged from 2.6 cm to 17.5 cm with a mean of 8.7 cm. All tumors density was inhomogeneous and heterogeneous enhancement. MGISTs with highly malignant located in small intestine were about 30% higher than stomach. The ＂satellite＂ turnouts were found in 6 cases with high malignant risk. 7 cases were suffered from liver metastasis, and 4 cases went with seeding into the abdominal cavity, 1 cases went with lymph node metastasis. Histologically, 19 cases （95%） were of spindle cell type. Immunohistochemical stains demonstrated a strong positivity for both c-kit （CDl17） and CD34s enhancement in 19 （95%）. Conclusion： Clinical expression is varied in MGIST patients. Female might be predominance in MGIST. The GISTs located in small intestine would tend to be more aggressive. The satellite tumours, necrosis and cystic degeneration were strongly benefit for MGIST diagnosis. Further

关 键 词：malignant gastrointestinal stromal tumor （MGIST） computer tomography （CT） METASTASIS CLINICOPATHOLOGY 

分 类 号：S851.347[农业科学—预防兽医学] TH774[农业科学—兽医学]