生产源区人血中多溴联苯醚水平与甲状腺激素相关性研究  

Correlations Between PBDEs and Thyroid Hormone Concentrations in Adults from Production Source Area

作　　者：李明圆[1] 金军[1] 杨从巧[1] 王英[1] 丁问微[1] 杨先丰 刘安明 

机构地区：[1]中央民族大学生命与环境科学学院,北京100081 [2]潍坊滨海人民医院,潍坊262737

出　　处：《环境科学》2011年第11期3271-3276,共6页Environmental Science

基　　金：国家自然科学基金项目(20507023);高等学校学科创新引智计划项目(B08044);中央民族大学(985)项目(CUN985-3-3);新世纪优秀人才支持计划项目(NCET-10-0106)

摘　　要：采用气相色谱/负化学电离源-质谱法对莱州湾南岸地区十溴联苯醚生产源区36位居民血清中的5种多溴联苯醚浓度进行了检测,同时测定了样品中的甲状腺激素水平.血清中Σ5PBDEs(BDE-28、-47、-153、-183、-209)的质量浓度范围(以脂重计算,下同)为130.3～4 478.4 ng.g-1,平均值为529.9 ng.g-1.5种同族体中,BDE-209对Σ5PBDEs的平均贡献率达到了69.8%.在与甲状腺激素水平的相关性研究中,计算了两者的Spearman秩相关系数,结果显示BDE-28、-47、-153、-183与TSH水平呈高度负相关,BDE-183与fT4水平呈现显著性负相关,而BDE-28、-47与T3,BDE-28、-153、-183与fT3之间均呈现显著性正相关.本研究中,生产源区人体血清中PBDEs水平处于较高的暴露水平,主要同类物为BDE-209,人体对PBDEs的暴露会影响上述4种甲状腺激素的水平,PBDEs对人体的影响不容忽视,有关PBDEs暴露水平与甲状腺激素水平之间的相关性,应进一步深入研究.Polybrominated diphenyl ethers（PBDEs） concentrations in 36 resident serum samples from PBDEs production source area were analyzed by gas chromatography/negative chemical ionization/mass spectrometry（GC-NCI-MS） method,and the concentrations of thyroid hormones were determined as well.The 5PBDEs（BDE-28,-47,-153,-183,-209） concentrations（lipid weight） in serum ranged from 130.3 to 4 478.4 ng·g-1,with an average value of 529.9 ng·g-1.BDE-209 was a dominant PBDE congener,on average accounting for 69.8% of the total PBDEs concentrations.Spearman rank correlation coefficient was calculated between PBDEs and thyroid hormone,it showed that there were high significant negative correlation between BDE-28,-47,-153,-183 and thyroid-stimulating hormone（TSH）,and significant negative correlation was also found between BDE-183 and free thyroxine（fT4）.Additionally,there were significant positive correlation between BDE-28,-47 and triiodothyronine（T3）,as well as between BDE-28,-153,-183 and free triiodothyronine（fT3）.In summary,the concentrations of PBDEs in serum in this study were at a high level,and BDE-209 was the predominant congener.The exposure to the PBDEs may affect thyroid hormone levels,and the further research should focus on the relationship between PBDEs and thyroid hormone concentrations.

关 键 词：多溴联苯醚 血清 甲状腺激素 相关性 生产源区 

分 类 号：X131[环境科学与工程—环境科学]