晚期食管鳞癌上MRP、ToPoⅡ的表达及其意义  

Expression of MRP and ToPoⅡand their correlation in locally advanced esophageal squamous cell carcinoma

作　　者：盛李明[1] 张丽珍[1] 孙晓江[1] 许亚萍[1] 马胜林[1] 

机构地区：[1]浙江省肿瘤医院放疗科,浙江杭州310022

出　　处：《中国农村卫生事业管理》2011年第10期1097-1099,共3页Chinese Rural Health Service Administration

基　　金：中国癌症基金会重点项目(基金编号:1002)

摘　　要：目的:检测MRP和ToPo在局部晚期食管鳞癌上的表达及与临床病理因素的关系。方法:使用免疫组化方法检测275例局部晚期食管鳞癌上MRP和ToPo的表达情况并分析其与临床病理因素的关系。结果:MRP高表达率为42.9%,高表达与T分期和脉管侵犯有关(P<0.05),ToPo低表达率为60.0%,低表达率亦与T分期和脉管侵犯有关,两者表达情况与性别、年龄、肿瘤细胞分化程度、淋巴结转移情况等无关。结论:共同检测MRP和ToPo情况有利于判断局部食管癌浸润情况,同时可应用于预测食管癌化疗敏感性,有利于化疗个体化进行。Objective To explore the expressions of MRP and ToPoⅡand their correlation in locally advanced esophageal squamous cell carcinoma.Methods The expressions of MRP and ToPoⅡwere detected in tissues from cancer by immunohistochemistry.The expressions and their relationship with the pathological factors were analyzed.Results High expression rate immunostaining for MRP protein was detected in 118 cases（42.9%）,and the expression was associated with T stage and lymphovascular invasion（P0.05）.Low expression rate immunostaining for ToPoⅡ protein was detected in a majority of cases（60.0%）,and the expression was associated with T stage and lymphovascular invasion（P0.05）.There was no significant difference between MRP,ToPoⅡ and gender,age,tumor cell differentiation and regional lymph nodes metastasis.The multivariate analysis showed that patients with T3 and negative lymphovascular invasion had an increased risk of high expression of MRP（P0.05）.Patients with T3 and tumor diameter less than 5 cm had an increased risk of low expression of ToPoⅡ（P0.05）.Conclusion Co-examining MRP and ToPoⅡmight evaluate the potential power of esophageal carcinoma invasion.The expression of MRP and ToPoⅡare important predictors of chemotherapy.Assessment of MRP and ToPoⅡmay be benefitial to select individual chemotherapy drugs to improve the treatment of esophageal carcinoma.

关 键 词：食管癌 MRP ToPoⅡ 化疗 

分 类 号：R735.1[医药卫生—肿瘤]