P16和CK17在区分宫颈非典型未成熟鳞化(AIM)和高级别鳞状上皮内瘤变(CINⅢ)的意义  

Significances of P16 and CK17 in discrimination of atypical immature squamous metaplasia and cervical intraepithelial neoplasia Ⅲ

作　　者：邵馨[1,2] 陶丽丽[1,2] 陈同钰[3,4] 

机构地区：[1]南京中医药大学附属医院 [2]常州市中医医院病理科,江苏常州213003 [3]苏州大学附属医院 [4]常州第一人民医院病理科

出　　处：《中国妇幼保健》2011年第28期4442-4444,共3页Maternal and Child Health Care of China

摘　　要：目的:通过检测P16和CK17在宫颈不成熟鳞化(AIM)和高级别鳞状上皮内瘤变(CINⅢ级)中的表达,探讨其临床病理意义。方法:采用免疫组化法检测P16和CK17在宫颈成熟鳞化(12例)、AIM(18例)和CINⅢ级(20例)表达情况。结果:12例宫颈成熟鳞化的病例均P16(-)/CK17(-),20例CINⅢ级均P16(+)/CK17(-),18例诊断为AIM的病例,3例P16(+)/CK17(+),5例P16(+)/CK17(-),均重新归入CINⅢ;10例P16(-)/C K17(+),归为鳞化。结论:AIM作为一个诊断性描述的名称,部分包含了CINⅢ级病变;免疫组化检测P16和CK17的表达在一定程度上有助于区分这两种病变。Objective：To explore the clinical pathological significances of P16 and CK17 by detecting the expressions of P16 and CK17 in atypical immature squamous metaplasia（AIM） and cervical intraepithelial neoplasia（CIN）Ⅲ.Methods：Immunohistochemical method was used to detect the expressions of P16 and CK17 in 12 cases with cervical mature metaplasia,18 cases with AIM and 20 cases with CINⅢ.Results：The expressions of P16 and CK17： ①12 cases with cervical mature metaplasia： P16（-）/CK17（-）;②20 cases with CINⅢ： P16（＋）/CK17（-）;③18 cases with AIM： 3 cases： P16（＋）/CK17（＋）,5 cases： P16（＋）/CK17（-）,they were classified as CIN Ⅲ,10 cases： P16（-）/CK17（＋）,they were reclassified as metaplasia.Conclusion：AIM includes some of CIN Ⅲ as a diagnostic descriptor,immunohistochemical detection of P16 and CK17 is helpful to distinguish CINⅢ from AIM to a certain extent.

关 键 词：宫颈不典型未成熟鳞化(AMI) 高级别鳞状上皮内瘤变(CINⅢ) P16 CK17 免疫组化 

分 类 号：R36[医药卫生—病理学]