Prostasin和Claudin-3在卵巢上皮性癌中的表达及意义  

Expressions and significances of Prostasin and Claudin-3 in epithelial ovarian cancer

作　　者：尹相力[1] 孔红霞[1] 

机构地区：[1]郑州大学第三附属医院妇科,河南郑州450052

出　　处：《中国妇幼保健》2011年第30期4672-4674,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨前列腺蛋白(Prostasin)和紧密连接蛋白3(Claudin-3)在卵巢上皮性癌中的表达及临床意义。方法:采用免疫组化SP法检测Prostasin和Claudin-3在50例卵巢上皮性癌、20例卵巢交界性肿瘤、20例卵巢良性肿瘤、20例正常卵巢组织中的表达情况。结果:Prostasin和Claudin-3在卵巢上皮性癌中的表达均明显高于其他三组(P<0.05),二者在卵巢上皮性癌中的表达与组织病理分级、临床分期有关(P<0.05),与组织学分型无关(P>0.05);Prostasin和Claudin-3在卵巢上皮性癌中的表达呈正相关(r=0.386,P<0.05)。结论:Prostasin和Claudin-3的表达升高与卵巢上皮性癌的发生、发展密切相关,Prostasin和Claudin-3有可能成为治疗卵巢癌的新靶点。Objective：To explore the expressions and significances of Prostasin and Claudin-3 in ovarian epithelial cancer. Methods：Immunohistochemical SP method was used to detect the expression levels of Prostasin and Claudin-3 in 50 cases with ovarian epithelial cancer,20 cases with borderline ovarian tumor,20 cases with benign ovarian tumor and 20 cases with normal ovarian tissues. Results：The expression levels of Prostasin and Claudin-3 in ovarian epithelial cancer were significantly higher than those in the other three groups（P0.05）.The expression levels of Prostasin and Claudin-3 in ovarian epithelial cancer were related to histopathological grade and clinical stage（P0.05）,but they were not correlated with histological types（P0.05）;there was positive correlation between Prostasin expression and Claudin-3 expression in ovarian epithelial cancer（γ=0.386,P0.05）. Conclusion：The high expressions of Prostasin and Claudin-3 are correlated with the occurrence and development of ovarian epithelial cancer.Prostasin and Claudin-3 may become new targets for treatment of ovarian cancer.

关 键 词：前列腺蛋白 紧密连接蛋白3 卵巢上皮性癌 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]