Secondary metabolites from fungus Alternaria sp. CIB 108  

作　　者：Qian Feng Chen Min Zhou Tao Yang Xiao Zhen Chen Chun Wang Guo Lin Zhang Guo You Li 

机构地区：[1]Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China [2]School of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China [3]Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Chinese Chemical Letters》2011年第10期1226-1228,共3页中国化学快报（英文版）

基　　金：supported financially by the NSFC(No.20902089 to G.Y.Li);the Knowledge Innovation Program of the Chinese Academy of Sciences(No.KSCX2-EW-G-13-04)

摘　　要：A new compound,3-butyryl-6-[rel-（1S,2S）-1,2-dihydroxypropyl]-4-hydroxy-2H-pyran-2-one（1）,was isolated from the solid fermented rice culture of Alternaria sp.CIB 108,along with three known ones,deoxyradicinin（2）,3-epiradicinol（3）,and 3- epideoxyradicinol（4）.Their structures were elucidated on the basis of spectroscopic data.The single crystal X-ray diffraction was applied to further clarify the structure of 1.Furthermore,compounds 1-4 possessed no cytotoxicity against several cell lines（HeLa, HepG2,and Ros） and showed no antibacterial activity at 40μmol/L.A new compound,3-butyryl-6-[rel-（1S,2S）-1,2-dihydroxypropyl]-4-hydroxy-2H-pyran-2-one（1）,was isolated from the solid fermented rice culture of Alternaria sp.CIB 108,along with three known ones,deoxyradicinin（2）,3-epiradicinol（3）,and 3- epideoxyradicinol（4）.Their structures were elucidated on the basis of spectroscopic data.The single crystal X-ray diffraction was applied to further clarify the structure of 1.Furthermore,compounds 1-4 possessed no cytotoxicity against several cell lines（HeLa, HepG2,and Ros） and showed no antibacterial activity at 40μmol/L.

关 键 词：Altemaria FERMENTATION PYRONE 

分 类 号：Q946.8[生物学—植物学] TE319[石油与天然气工程—油气田开发工程]