艾司西酞普兰与氯米帕明治疗脑外伤后抑郁临床对照观察  

Ai Company Citalopram and Chlorine M Palmer Ming Treatment after Traumatic Brain Controlled Clinical Observation of Depression

作　　者：张彦恒[1,2] 王继伟[3] 张立敏[1,2] 邓春继[1,2] 

机构地区：[1]河北省精神卫生中心 [2]河北省第六人民医院心理科,保定071000 [3]河北大学附属医院神经内科,保定071000

出　　处：《中国医药导刊》2011年第7期1210-1211,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:比较艾司西酞普兰与氯米帕明治疗脑外伤后抑郁的疗效和安全性。方法:将60例脑外伤后抑郁患者随机分为两组,分别用艾司西酞普兰与氯米帕明片治疗8周。采用汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)和副反应量表(TESS)于治疗前和治疗1、2、4、8周末分别评定疗效和不良反应。结果:两组显效率分别为80%和83.3%疗效相当(P>0.05)。治疗8周末HAMD和SDS评分均较治疗前下降(P<0.05),HAMD及SDS评分艾司西酞普兰组治疗第一周末即显著下降,而氯米帕明组第二周末才显著下降。副反应方面,艾司西酞普兰组以失眠为主。氯米帕明组以口干,便秘,心悸为主。结论:艾司西酞普兰是治疗脑外伤后抑郁安全有效的药物。Objective：More ai company citalopram and chlorine m palmer Ming treatment after traumatic brain depression efficacy and safety.Methods：60 patients with depressionafter brain injury patients were randomly divided into two groups,respectively for ai company citalopram and chlorine m palmer Ming eight weeks of treatment.The Hamilton depression rating scale （HAMD）,depression self rating scale （SDS） and side effects scale （the treatment before treatment, and treatment in 1,2,4,8 weekend evaluation respectively curative effect and adverse reactions.Results：Two groups of significant efficiency 80% and 83.3%,respectively （P〉0.05 treatment group）.8 HAMD SDS and treatment weekend scores are a drop before treatment （P〈0.05）,HAMD and SDS score ai company citalopram treatment group is the first weekend decreased significantly, and chlorine m palmer Ming group the second weekend to Significantly, Side effects,ai company citalopram group for insomnia primarily.Chlorine m palmer Ming group for dry mouth,constipation,palpitations primarily.Conelusion：Aicompany citalopram is the treatment of depression after traumatic brain safe and effective drugs.

关 键 词：艾司西酞普兰 氯米帕明 脑外伤后抑郁 病例对照研究 

分 类 号：R749.1[医药卫生—神经病学与精神病学]