周剂量吉西他滨联合苦参素胸腔灌注治疗非小细胞肺癌患者胸腔积液的疗效观察  

Effect of Non-smallcell Lung Cancer Patients Accompanied by Pleural Effusion with Weekly Doses of Gemcitabine Combine Oxymatrine by Intrapleural Infusion

作　　者：欧立文[1] 曹爱国[1] 卢平[1] 李之茂[1] 

机构地区：[1]湘南学院附属医院呼吸科,郴州423000

出　　处：《中国医药导刊》2011年第8期1354-1355,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:评价周剂量吉西他滨联合苦参素胸腔灌注治疗非小细胞肺癌患者胸腔积液的疗效和安全性。方法:68例非小细胞肺癌并胸腔积液患者随机分为对照组和观察组。对照组在常规治疗基础上加吉西他滨和地塞米松胸腔灌注。观察组在对照组基础上加苦参素胸腔灌注。评价2组患者疗效和安全性。结果:观察组疗效优于对照组,骨髓抑制作用低于对照组,差异有显著性。结论:苦参素协同吉西他滨提高非小细胞肺癌患者胸腔积液的疗效,减少不良反应,增加耐受力,值得临床推广。Objective：To evaluate effect and safety of non-smallcell lung cancer accompanied by pleural effusion patients with weekly doses of gemeitabine combine oxymatrine by intrapleural infusion.Methods：Sixty-eight non-smallcell lung cancer accompanied by plcural effusion patients were randomly divided into control groups and observation groups. Control groups were on the basis of convetional therapy plused gemcitabine and dexamethasone intrapleural infusion.Observation1 groups were on the basis of control groups plused oxymatdne intrapleural infusion.Efficacy and safety were evaluated.Results： Efficacy of observation groups were better than those of conlrol groups, but bone marrow suppression of observation groups were less than those of control groups.and difference were significant.Conelusion：Oxymatrine could be synergistic with gemcitabine to improve efficacy, reduce adverse reactions,increase tolerance of non-smallcell lung cancer accompanied by pleural effusion tgatients, and worthy oforomotion.

关 键 词：吉西他滨 苦参素 非小细胞肺癌 胸腔积液 疗效 安全性 

分 类 号：R734.2[医药卫生—肿瘤]